The Effect of Proton Pump Inhibitors on Fracture Formation and Reflection on Care

Abstract

Proton pump inhibitors (PPI) are used in gastrointestinal system diseases and nonsteroidal anti-inflammatory drugs to prevent side effects of gastrointestinal system. Studies in our country have shown the increase in the use of proton pump inhibitors over the years. As it exists in all drugs, the use of proton pump inhibitors may cause some undesirable effects.These side effects can be considered in two groups as short and long term side effects. Increased risk of bone fracture is one of the side effects associated with the long-term use of proton pump inhibitors. A my riad of theories have been proposed regarding the causes of proton pump inhibitors leading to bone fracture. The results obtained from the meta-analysis and systematic reviews conducted in recent years support that they predispose to the fracture and suggest that hip fractures, vertebral fractures, wrist and forearm fractures are several times higher in those who use proton pump inhibitors for more than one year than those who do not use proton pump inhibitors.It is reported that the risk of fracture is higher especially in elderly and women. This review was written to draw attention to the risks posed by the use of PPI and to guide the planning of care.

Keywords

• drug related side effect
• fractures
• proton pump inhibitors