Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

Xavier Brenachot; Giorgio Ramadori; Rafael M. Ioris; Christelle Veyrat-Durebex; Jordi Altirriba; Ebru Aras; Sanda Ljubicic; Daisuke Kohno; Salvatore Fabbiano; Sophie Clement; Nicolas Goossens; Mirko Trajkovski; Sheila Harroch; Francesco Negro; Roberto Coppari

doi:10.1038/s41467-017-02074-2

Nature Communications (Nov 2017)

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

Xavier Brenachot,
Giorgio Ramadori,
Rafael M. Ioris,
Christelle Veyrat-Durebex,
Jordi Altirriba,
Ebru Aras,
Sanda Ljubicic,
Daisuke Kohno,
Salvatore Fabbiano,
Sophie Clement,
Nicolas Goossens,
Mirko Trajkovski,
Sheila Harroch,
Francesco Negro,
Roberto Coppari

Affiliations

Xavier Brenachot: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Giorgio Ramadori: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Rafael M. Ioris: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Christelle Veyrat-Durebex: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Jordi Altirriba: Diabetes Center of the Faculty of Medicine, University of Geneva
Ebru Aras: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Sanda Ljubicic: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Daisuke Kohno: Advanced Scientific Research Leaders Development Unit, Gunma University
Salvatore Fabbiano: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Sophie Clement: Clinical Pathology, Geneva University Hospitals, Rue Gabrielle Perret-Gentil
Nicolas Goossens: Gastroenterology and Hepatology, Geneva University Hospitals, Rue Gabrielle Perret-Gentil
Mirko Trajkovski: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Sheila Harroch: Department of Psychiatry, New York University Langone School of Medicine
Francesco Negro: Diabetes Center of the Faculty of Medicine, University of Geneva
Roberto Coppari: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva

DOI: https://doi.org/10.1038/s41467-017-02074-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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