CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis

Abstract

Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats.

Keywords

• White matter injury
• Necrotizing enterocolitis
• Gut–Brain axis
• CXCL1
• CXCR2