High Sensitivity C-Reactive Protein (hs-CRP) and Uric Acid as Markers of Cardiovascular Risk in Chronic Kidney Disease Patients

Abstract

Background & Aims: The link between Chronic Kidney Disease (CKD) and Cardio Vascular Disease (CVD) has long been established. Hyperuricemia and inflammatory markers such as hs-CRP are considered to be non-traditional risk factors for cardiovascular risk in CKD patients. The aim of this study was to estimate serum hs-CRP and uric acid levels in patients with chronic kidney disease along with age and sex matched healthy controls and see whether they are statistically significant or not. Materials & Methods: In this case-control study, totally 30 cases with ages varied from 30-70 years and 30 age and sex matched controls were selected based on inclusion and exclusion criteria. Serum CRP and Uric Acid were analyzed on Beckman Coulter AU-480 fully automated analyser, by Turbidimetric end point method and Modified Trinder end point method, respectively. Qualitative data is expressed as proportion and percentage while quantitative data is expressed as mean+SD. Statistical analysis is done using Microsoft Excel sheet and Graph pad software. A p value <0.05 is considered as statistically significant. Results: Results show that the patients with CKD had higher levels of hs-CRP and Uric Acid than healthy controls, implying a higher risk of cardiovascular disease in this group. Conclusion: The present study implies that regular monitoring of these biomarkers is required in CKD patients, to assess the progression of atherosclerosis and evaluate potential interventions, thereby preventing morbidity & mortality due to cardiovascular disease.

Keywords

• chronic kidney disease
• serum hs-crp
• serum uric acid