The study of oncolytic viruses reproduction in organ cultures of human lymphoid tumors

Abstract

Oncolytic viruses are promising agents for the treatment of various types of tumors, including malignant non-Hodgkin lymphomas. In order to identify the most effective candidates from a wide panel of non-pathogenic antitumor strains, a study was carried out of their ability to reproduce in short-term cultures of lymphoid tumor cells. Also, tumor cell cultures were characterized in relation to the presence of specific viral receptors CD54, CD55, CD155 on their surface.

Keywords

• oncolytic viruses
• lymphomas
• chemotherapy
• immunotherapy
• cell cultures