The elongation factor Spt5 facilitates transcription initiation for rapid induction of inflammatory-response genes

Abstract

A subset of inflammatory-response NF-κB target genes is activated immediately after proinflammatory stimulation. Here, the authors show that in rapidly induced genes, depletion of the elongation factor Spt5 reduces transcription initiation and TFIID–promoter association without affecting the transcription elongation rate.