Molecular & Cellular Oncology (Jan 2017)
Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter
Abstract
Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.
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