Nature Communications (Aug 2020)
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
- Rouven Hoefflin,
- Sabine Harlander,
- Silvia Schäfer,
- Patrick Metzger,
- Fengshen Kuo,
- Désirée Schönenberger,
- Mojca Adlesic,
- Asin Peighambari,
- Philipp Seidel,
- Chia-yi Chen,
- Miguel Consenza-Contreras,
- Andreas Jud,
- Bernd Lahrmann,
- Niels Grabe,
- Danijela Heide,
- Franziska M. Uhl,
- Timothy A. Chan,
- Justus Duyster,
- Robert Zeiser,
- Christoph Schell,
- Mathias Heikenwalder,
- Oliver Schilling,
- A. Ari Hakimi,
- Melanie Boerries,
- Ian J. Frew
Affiliations
- Rouven Hoefflin
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Sabine Harlander
- Institute of Physiology, University of Zurich
- Silvia Schäfer
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Patrick Metzger
- Faculty of Biology, University of Freiburg
- Fengshen Kuo
- Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center
- Désirée Schönenberger
- Institute of Physiology, University of Zurich
- Mojca Adlesic
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Asin Peighambari
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Philipp Seidel
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Chia-yi Chen
- Institute for Surgical Pathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Miguel Consenza-Contreras
- Institute for Surgical Pathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Andreas Jud
- Department of General and Visceral Surgery, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Bernd Lahrmann
- Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg
- Niels Grabe
- Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg
- Danijela Heide
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Franziska M. Uhl
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Timothy A. Chan
- Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center
- Justus Duyster
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Robert Zeiser
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Christoph Schell
- Institute for Surgical Pathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- Mathias Heikenwalder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Oliver Schilling
- Institute for Surgical Pathology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- A. Ari Hakimi
- Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center
- Melanie Boerries
- Institute of Medical Bioinformatics and Systems Medicine, Medical Centre—University of Freiburg, Faculty of Medicine, University of Freiburg
- Ian J. Frew
- Department of Medicine I, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-020-17873-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect.
