Nature Communications (Aug 2020)

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

  • Rouven Hoefflin,
  • Sabine Harlander,
  • Silvia Schäfer,
  • Patrick Metzger,
  • Fengshen Kuo,
  • Désirée Schönenberger,
  • Mojca Adlesic,
  • Asin Peighambari,
  • Philipp Seidel,
  • Chia-yi Chen,
  • Miguel Consenza-Contreras,
  • Andreas Jud,
  • Bernd Lahrmann,
  • Niels Grabe,
  • Danijela Heide,
  • Franziska M. Uhl,
  • Timothy A. Chan,
  • Justus Duyster,
  • Robert Zeiser,
  • Christoph Schell,
  • Mathias Heikenwalder,
  • Oliver Schilling,
  • A. Ari Hakimi,
  • Melanie Boerries,
  • Ian J. Frew

Journal volume & issue
Vol. 11, no. 1
pp. 1 – 21


Read online

Genetic inactivation of VHL leads to stabilization of HIF-1α/HIF-2α and is associated with clear cell renal cell carcinoma (ccRCC) initiation and progression. Using an autochthonous mouse model of ccRCC with Vhl deletion, here the authors show that HIF-1α is necessary for tumor formation, while HIF-2α deletion has only a moderate effect.