Zhejiang Daxue xuebao. Lixue ban (Sep 2001)

Current status and prospects of antitumor nucleoside agents whose activities are mediated by deoxycytidine kinase(脱氧胞苷激酶介导的核苷类似物抗肿瘤药物的现状及前景)

  • HANNing(韩凝),
  • MINGZheng-huan(明镇寰),
  • ZHUMu-yuan(朱睦元)

DOI
Journal volume & issue
Vol. 28, no. 5
pp. 567 – 571

Abstract

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ara-C，CNDAC等核苷类似物药物通过与DNA链的结合，抑制DNA合成，导致细胞死亡，从而发挥其抗肿瘤活性.它们的活化必须借助于脱氧胞苷激酶的磷酸化作用.本文介绍了此类药物的细胞毒性机制和药物抗性机制的研究进展，并对其发展前景进行了展望.

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