Possible Prosthetic Valve Endocarditis by Pandoraea pnomenusa and Specific Virulence Mechanisms

Abstract

Elias Bodendoerfer, 1 Nicolas Personnic, 1 Carlos A Mestres, 2 Markus J Wilhelm, 2 Lilly Meyer, 3 Barbara Hasse 3 1University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland; 2University Hospital Zurich, Clinic for Cardiac Surgery, Zurich, Switzerland; 3University Hospital Zurich, Department of Infectious Diseases and Hospital Epidemiology, Zurich, SwitzerlandCorrespondence: Elias BodendoerferInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 28/30, Zürich, CH-8006, SwitzerlandTel [phone]Email [email protected]: Bacteremia by Pandoraea spp. has rarely been described before. We report the first case of a P. pnomenusa possible prosthetic valve endocarditis, according to the modified Duke criteria, in a 37-year old male injecting drug user suffering from recurrent endocarditis. Furthermore, we demonstrate biofilm formation by the P. pnomenusa isolates of this patient and investigate antibiotic resistance.Keywords: prosthetic valve endocarditis, central venous catheter, bacteremia, Pandoraea pnomenusa, biofilm formation, antibiotic resistance

Keywords

• prosthetic valve endocarditis
• central venous catheter
• bacteremia
• pandoraea pnomenusa
• biofilm formation
• antibiotic resistance