Cell Death Discovery (Jul 2022)

N6-methyladenosine (m6A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner

Hao Shen,
Keliang Xie,
Miaomiao Li,
Qianyu Yang,
Xiaoye Wang

Affiliations

Hao Shen: Department of Intensive Care Unit, Tianjin Medical University General Hospital
Keliang Xie: Department of Intensive Care Unit, Tianjin Medical University General Hospital
Miaomiao Li: Department of Pediatric surgery, Tianjin Children’s Hospital
Qianyu Yang: Department of Pediatric surgery, Tianjin Children’s Hospital
Xiaoye Wang: Department of Intensive Care Unit, Tianjin Medical University General Hospital

DOI: https://doi.org/10.1038/s41420-022-01099-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

METTL3 promotes LPS-induced cardiomyocytes inflammatory damage via IGF2BP1/m6A/HDAC4 axis.

Published in Cell Death Discovery

ISSN: 2058-7716 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: http://www.nature.com/cddiscovery/

About the journal