Nature Communications (Sep 2018)
UBL3 modification influences protein sorting to small extracellular vesicles
- Hiroshi Ageta,
- Natsumi Ageta-Ishihara,
- Keisuke Hitachi,
- Ozge Karayel,
- Takanori Onouchi,
- Hisateru Yamaguchi,
- Tomoaki Kahyo,
- Ken Hatanaka,
- Koji Ikegami,
- Yusuke Yoshioka,
- Kenji Nakamura,
- Nobuyoshi Kosaka,
- Masashi Nakatani,
- Akiyoshi Uezumi,
- Tomihiko Ide,
- Yutaka Tsutsumi,
- Haruhiko Sugimura,
- Makoto Kinoshita,
- Takahiro Ochiya,
- Matthias Mann,
- Mitsutoshi Setou,
- Kunihiro Tsuchida
Affiliations
- Hiroshi Ageta
- Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- Natsumi Ageta-Ishihara
- Division of Biological Sciences, Department of Molecular Biology, Nagoya University Graduate School of Science
- Keisuke Hitachi
- Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- Ozge Karayel
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Takanori Onouchi
- Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho
- Hisateru Yamaguchi
- Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- Tomoaki Kahyo
- Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya
- Ken Hatanaka
- Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya
- Koji Ikegami
- Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya
- Yusuke Yoshioka
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku
- Kenji Nakamura
- Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya
- Nobuyoshi Kosaka
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku
- Masashi Nakatani
- Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- Akiyoshi Uezumi
- Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- Tomihiko Ide
- Laboratory of Electron Microscopy, Fujita Health University Joint research support promotion facility, 1-98 Dengakugakubo, Kutsukake-cho
- Yutaka Tsutsumi
- Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho
- Haruhiko Sugimura
- Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu
- Makoto Kinoshita
- Division of Biological Sciences, Department of Molecular Biology, Nagoya University Graduate School of Science
- Takahiro Ochiya
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Mitsutoshi Setou
- Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya
- Kunihiro Tsuchida
- Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho
- DOI
- https://doi.org/10.1038/s41467-018-06197-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.
