Primary breast parenchyma melanoma: case report

Abstract

Introduction: Primary breast melanoma is a rare condition and most of cases are associated with melanoma overlying the skin of the breast or metastatic disease site. Primary breast parenchyma melanoma (PBPM) is extremely uncommon with only seven cases reported in the last four decades. Case report: A 44-year-old woman presented with a progressive growth lesion on the right breast in the last 6 months. Initial core biopsy suggested poor differentiated malignant round cells tumor with immunohistochemical confirming melanoma diagnosis. Patient underwent radical modified right mastectomy with final pathological report revealing the diagnosis of PBPM, 10cm x 9cm x 7cm in size. Discussion: After active search on PubMed/MEDLINE database, few case reports were found about PBPM. Radical mastectomy with axillar complete node dissection was the most common initially management. Prognostic was poor in general and only one case presented with no evidence of disease after 1-year follow-up.

Keywords

• breast neoplasms
• melanoma
• breast diseases