Frontiers in Psychiatry (Mar 2024)

Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission

  • Anna Giménez-Palomo,
  • Anna Giménez-Palomo,
  • Anna Giménez-Palomo,
  • Anna Giménez-Palomo,
  • Mariona Guitart-Mampel,
  • Gemma Roqué,
  • Ester Sánchez,
  • Roger Borràs,
  • Roger Borràs,
  • Ana Meseguer,
  • Francesc Josep García-García,
  • Esther Tobías,
  • Laura Valls-Roca,
  • Gerard Anmella,
  • Gerard Anmella,
  • Gerard Anmella,
  • Gerard Anmella,
  • Marc Valentí,
  • Marc Valentí,
  • Marc Valentí,
  • Marc Valentí,
  • Luis Olivier,
  • Luis Olivier,
  • Luis Olivier,
  • Luis Olivier,
  • Oscar de Juan,
  • Oscar de Juan,
  • Oscar de Juan,
  • Oscar de Juan,
  • Iñaki Ochandiano,
  • Iñaki Ochandiano,
  • Iñaki Ochandiano,
  • Iñaki Ochandiano,
  • Helena Andreu,
  • Helena Andreu,
  • Helena Andreu,
  • Helena Andreu,
  • Joaquim Radua,
  • Joaquim Radua,
  • Joaquim Radua,
  • Joaquim Radua,
  • Norma Verdolini,
  • Michael Berk,
  • Michael Berk,
  • Eduard Vieta,
  • Eduard Vieta,
  • Eduard Vieta,
  • Eduard Vieta,
  • Glòria Garrabou,
  • Josep Roca,
  • Xavier Alsina-Restoy,
  • Isabella Pacchiarotti,
  • Isabella Pacchiarotti,
  • Isabella Pacchiarotti,
  • Isabella Pacchiarotti

DOI
https://doi.org/10.3389/fpsyt.2024.1386286
Journal volume & issue
Vol. 15

Abstract

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BackgroundAerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD.MethodsThis study included eight BD patients admitted to an acute psychiatric unit. Incremental cardiopulmonary exercise test (CPET) was conducted during acute episodes (T0), followed by constant work rate cycle ergometry (CWRCE) to evaluate endurance time, oxygen uptake at peak exercise (VO2peak) and at the anaerobic threshold. The second test was repeated during remission (T1). Mitochondrial respiration rates were assessed at T0 and T1 in peripheral blood mononuclear cells.ResultsEndurance time, VO2peak, and anaerobic threshold oxygen consumption showed no significant variations between T0 and T1. Basal oxygen consumption at T1 tended to inversely correlate with maximal mitochondrial respiratory capacity (r=-0.690, p=0.058), and VO2peak during exercise at T1 inversely correlated with basal and minimum mitochondrial respiration (r=-0.810, p=0.015; r=-0.786, p=0.021, respectively).ConclusionsOur preliminary data showed that lower basal oxygen consumption may be linked to greater mitochondrial respiratory capacity, and maximum oxygen uptake during the exercise task was associated with lower basal mitochondrial respiration, suggesting that lower oxygen requirements could be associated with greater mitochondrial capacity. These findings should be replicated in larger samples stratified for manic and depressive states.

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