Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Elliot H. Akama-Garren; Theo van den Broek; Lea Simoni; Carlos Castrillon; Cees E. van der Poel; Michael C. Carroll

doi:10.1038/s41467-021-27035-8

Nature Communications (Nov 2021)

Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Elliot H. Akama-Garren,
Theo van den Broek,
Lea Simoni,
Carlos Castrillon,
Cees E. van der Poel,
Michael C. Carroll

Affiliations

Elliot H. Akama-Garren: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Theo van den Broek: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Lea Simoni: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Carlos Castrillon: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Cees E. van der Poel: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Michael C. Carroll: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-27035-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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