Study of the Embryonic Toxicity of TiO<sub>2</sub> and ZrO<sub>2</sub> Nanoparticles
Elena Nikolaevna Lyashenko,
Leyla Djavadovna Uzbekova,
Valeri Vladimirovna Polovinkina,
Anastasia Konstantinovna Dorofeeva,
Said-Umar Sithalil-ugli Ibragimov,
Arslan Ayavovich Tatamov,
Albina Gamdullaevna Avkaeva,
Anastasia Alekseevna Mikhailova,
Inga Shamilevna Tuaeva,
Ruslan Kazbekovich Esiev,
Sergei Dmitrievich Mezentsev,
Marina Alexandrovna Gubanova,
Natalya Grigorevna Bondarenko,
Alina Yurievna Maslova
Affiliations
Elena Nikolaevna Lyashenko
Department of Obstetrics and Gynecology, Faculty of Pediatrics, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, Russia
Leyla Djavadovna Uzbekova
Faculty of Pediatrics, Rostov State Medical University, 344009 Rostov-on-Don, Russia
Valeri Vladimirovna Polovinkina
Department of Obstetrics and Gynecology, Faculty of Pediatrics, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, Russia
Anastasia Konstantinovna Dorofeeva
Faculty of Pediatrics, Rostov State Medical University, 344009 Rostov-on-Don, Russia
Said-Umar Sithalil-ugli Ibragimov
Department of Obstetrics and Gynecology, Faculty of Pediatrics, S.I. Georgievsky Medical Academy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, Russia
Arslan Ayavovich Tatamov
Faculty of Medicine, Dagestan State Medical University, 367029 Makhachkala, Russia
Albina Gamdullaevna Avkaeva
Faculty of Medicine, Dagestan State Medical University, 367029 Makhachkala, Russia
Anastasia Alekseevna Mikhailova
Faculty of Medicine, Stavropol State Medical University, 355017 Stavropol, Russia
Inga Shamilevna Tuaeva
Department of Hygiene, Faculty of Medicine and Prevention, North Ossetian State Medical Academy, 362019 Vladikavkaz, Russia
Ruslan Kazbekovich Esiev
Department of Dentistry, North Ossetian State Medical Academy, 362019 Vladikavkaz, Russia
Sergei Dmitrievich Mezentsev
Department of the National Research, Moscow State University of Civil Engineering, 125009 Moscow, Russia
Marina Alexandrovna Gubanova
Armavir State Pedagogical University, 352901 Armavir, Russia
Natalya Grigorevna Bondarenko
Department of Philosophy of History of Law, Pyatigorsk Branch of North Caucasus Federal University, 357502 Pyatigorsk, Russia
Alina Yurievna Maslova
Faculty of Medicine, Stavropol State Medical University, 355017 Stavropol, Russia
Currently, the widespread use of TiO2 and ZrO2 nanoparticles (NPs) in various industries poses a risk in terms of their potential toxicity. A number of experimental studies provide evidence of the toxic effect of TiO2 and ZrO2 NPs on biological objects. In order to supplement the level of knowledge and assess the risks of toxicity and danger of TiO2 and ZrO2 NPs, we decided to conduct a comprehensive experiment to study the embryonic toxicity of TiO2 and ZrO2 NPs in pregnant rats. For the experiment, mongrel white rats during pregnancy received aqueous dispersions of powders of TiO2 and ZrO2 NPs at a dose of 100 mg/kg/day. To characterize the effect of TiO2 and ZrO2 NPs on females and the postnatal ontogenesis of offspring, a complex of physiological and biochemical research methods was used. The results of the experiment showed that TiO2 NPs as ZrO2 NPs (100 mg/kg per os) cause few shifts of similar orientation in the maternal body. Neither TiO2 NPs nor ZrO2 NPs have an embryonic and teratogenic effect on the offspring in utero, but both modify its postnatal development.
