Investigation of insulin resistance and vitamin E deficiency in chronic inflammatory demyelinatıng polyneuropathy: A 5-year retrospective study

Abstract

Objective: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a treatable disease; therefore, accurate diagnosis and detection of coexisting disorders are very important. Some authors have reported that CIDP was more frequently observed in patients with diabetes mellitus when compared with the population in general. Vitamin E deficiency leads to demyelinating neuropathy, and Vitamin E supplementation ensures clinical and electrophysiological recovery. In this study, identifying the association between insulin resistance, Vitamin E deficiency, and CIDP is aimed. Materials and Methods: Thirty-three patients with CIDP and forty healthy controls were evaluated. Two groups were compared in terms of insulin resistance and Vitamin E level status. Results: A statistically significant difference was not found between CIDP and control groups as for the distribution of mean ages, genders, Homeostatic Model Assessment Index values, impaired fasting glucose, and a statistically significant difference was not found between CIDP and control groups as for Vitamin E deficiency. Conclusion: Our study could not reveal any evidence about insulin resistance and Vitamin E deficiency in CIDP patients.

Keywords

• chronic inflammatory demyelinating polyneuropathy
• homeostatic model assessment
• insulin resistance
• vitamin e