Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level

Helen R. Clark; Connor McKenney; Nathan M. Livingston; Ariel Gershman; Seema Sajjan; Isaac S. Chan; Andrew J. Ewald; Winston Timp; Bin Wu; Abhyudai Singh; Sergi Regot

doi:10.1038/s41467-021-22070-x

Nature Communications (Mar 2021)

Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level

Helen R. Clark,
Connor McKenney,
Nathan M. Livingston,
Ariel Gershman,
Seema Sajjan,
Isaac S. Chan,
Andrew J. Ewald,
Winston Timp,
Bin Wu,
Abhyudai Singh,
Sergi Regot

Affiliations

Helen R. Clark: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Connor McKenney: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Nathan M. Livingston: The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine
Ariel Gershman: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Seema Sajjan: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Isaac S. Chan: Oncology Department, Johns Hopkins University School of Medicine
Andrew J. Ewald: Oncology Department, Johns Hopkins University School of Medicine
Winston Timp: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Bin Wu: Center for Cell Dynamics, Johns Hopkins University School of Medicine
Abhyudai Singh: Electrical and Computer Engineering, University of Delaware
Sergi Regot: Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-22070-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Fine tuning the immune response in line with the degree of threat is central to recognition of a pathogen versus commensal bacteria. Here the authors implicate a digital all-or-nothing cell response in control of the tissue level immune response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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