Frontiers in Immunology (Aug 2019)

Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection

  • Kwang-Soo Shin,
  • Insu Jeon,
  • Byung-Seok Kim,
  • Il-Kyu Kim,
  • Young-Jun Park,
  • Choong-Hyun Koh,
  • Boyeong Song,
  • Jeong-Mi Lee,
  • Jiyoung Lim,
  • Eun-Ah Bae,
  • Hyungseok Seo,
  • Young Ho Ban,
  • Sang-Jun Ha,
  • Chang-Yuil Kang,
  • Chang-Yuil Kang

DOI
https://doi.org/10.3389/fimmu.2019.01887
Journal volume & issue
Vol. 10

Abstract

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Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the secondary lymphoid organs during acute LCMV infection in an interferon-γ (IFN-γ)-dependent manner. We also found that priming by moDCs enhanced the differentiation of memory CD8+ T cells compared to differentiation primed by conventional dendritic cells (cDCs) through upregulation of Eomesodermin (Eomes) and T cell factor-1 (TCF-1) expression in CD8+ T cells. Consequently, impaired memory formation of CD8+ T cells in mice that had reduced numbers of moDCs led to defective clearance of pathogens upon rechallenge. Mechanistically, attenuated interleukin-2 (IL-2) signaling in CD8+ T cells primed by moDCs was responsible for the enhanced memory programming of CD8+ T cells. Therefore, our findings unveil a specialization of the antigen-presenting cell subsets in the fate determination of CD8+ T cells during infection and pave the way for the development of a novel therapeutic intervention on infection.

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