Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Hua Guan; Hua Guan; Jin Zhang; Jing Luan; Jing Luan; Hao Xu; Zhenghao Huang; Qi Yu; Xingchun Gou; Lixian Xu

doi:10.3389/fendo.2021.712217

Frontiers in Endocrinology (Aug 2021)

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Hua Guan,
Hua Guan,
Jin Zhang,
Jing Luan,
Jing Luan,
Hao Xu,
Zhenghao Huang,
Qi Yu,
Xingchun Gou,
Lixian Xu

Affiliations

Hua Guan: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anethesiology, School of Stomatology, Fourth Military Medical University, Xi’an, China
Hua Guan: Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
Jin Zhang: Department of Preventive Medicine, School of Stomatology, Fourth Military Medical University, Xi’an, China
Jing Luan: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anethesiology, School of Stomatology, Fourth Military Medical University, Xi’an, China
Jing Luan: Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
Hao Xu: Institution of Basic Medical Science, Xi’an Medical University, Xi’an, China
Zhenghao Huang: Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
Qi Yu: Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
Xingchun Gou: Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China
Lixian Xu: State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anethesiology, School of Stomatology, Fourth Military Medical University, Xi’an, China

DOI: https://doi.org/10.3389/fendo.2021.712217
Journal volume & issue: Vol. 12

Abstract

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Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

About the journal

Abstract

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