Communications Biology (May 2021)
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry
- Natasha Bertelsen,
- Isotta Landi,
- Richard A. I. Bethlehem,
- Jakob Seidlitz,
- Elena Maria Busuoli,
- Veronica Mandelli,
- Eleonora Satta,
- Stavros Trakoshis,
- Bonnie Auyeung,
- Prantik Kundu,
- Eva Loth,
- Guillaume Dumas,
- Sarah Baumeister,
- Christian F. Beckmann,
- Sven Bölte,
- Thomas Bourgeron,
- Tony Charman,
- Sarah Durston,
- Christine Ecker,
- Rosemary J. Holt,
- Mark H. Johnson,
- Emily J. H. Jones,
- Luke Mason,
- Andreas Meyer-Lindenberg,
- Carolin Moessnang,
- Marianne Oldehinkel,
- Antonio M. Persico,
- Julian Tillmann,
- Steve C. R. Williams,
- Will Spooren,
- Declan G. M. Murphy,
- Jan K. Buitelaar,
- the EU-AIMS LEAP group,
- Simon Baron-Cohen,
- Meng-Chuan Lai,
- Michael V. Lombardo
Affiliations
- Natasha Bertelsen
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Isotta Landi
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Richard A. I. Bethlehem
- Department of Psychiatry, University of Cambridge
- Jakob Seidlitz
- Department of Child and Adolescent Psychiatry and Behavioral Science, Children’s Hospital of Philadelphia
- Elena Maria Busuoli
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Veronica Mandelli
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Eleonora Satta
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Stavros Trakoshis
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- Bonnie Auyeung
- Department of Psychology, School of Philosophy, Psychology, and Language Sciences, University of Edinburgh
- Prantik Kundu
- Brain Mapping Unit, Department of Psychiatry, University of Cambridge
- Eva Loth
- Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Guillaume Dumas
- Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris
- Sarah Baumeister
- Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Christian F. Beckmann
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre
- Sven Bölte
- Department of Women’s and Children’s Health; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm
- Thomas Bourgeron
- Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris
- Tony Charman
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Sarah Durston
- Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Christine Ecker
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goethe University
- Rosemary J. Holt
- Autism Research Centre, Department of Psychiatry, University of Cambridge
- Mark H. Johnson
- Department of Psychology, University of Cambridge
- Emily J. H. Jones
- Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building
- Luke Mason
- Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building
- Andreas Meyer-Lindenberg
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Carolin Moessnang
- Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
- Marianne Oldehinkel
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre
- Antonio M. Persico
- Child and Adolescent Neuropsychiatry Unit, Gaetano Martino University Hospital, University of Messina
- Julian Tillmann
- Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Steve C. R. Williams
- Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Will Spooren
- Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel
- Declan G. M. Murphy
- Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Jan K. Buitelaar
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre
- the EU-AIMS LEAP group
- Simon Baron-Cohen
- Autism Research Centre, Department of Psychiatry, University of Cambridge
- Meng-Chuan Lai
- Autism Research Centre, Department of Psychiatry, University of Cambridge
- Michael V. Lombardo
- Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia
- DOI
- https://doi.org/10.1038/s42003-021-02015-2
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecular signatures in two of these subgroups, altogether highlighting subtle differences in neural circuitry and genomic networks that could underlie phenotypic differences among ASD patients.
