Advanced Science (Dec 2021)
Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y
- Yan Zhang,
- Chun‐Yuan Chen,
- Yi‐Wei Liu,
- Shan‐Shan Rao,
- Yi‐Juan Tan,
- Yu‐Xuan Qian,
- Kun Xia,
- Jie Huang,
- Xi‐Xi Liu,
- Chun‐Gu Hong,
- Hao Yin,
- Jia Cao,
- Shi‐Kai Feng,
- Ze‐Hui He,
- You‐You Li,
- Zhong‐Wei Luo,
- Ben Wu,
- Zi‐Qi Yan,
- Tuan‐Hui Chen,
- Meng‐Lu Chen,
- Yi‐Yi Wang,
- Zhen‐Xing Wang,
- Zheng‐Zhao Liu,
- Ming‐Jie Luo,
- Xiong‐Ke Hu,
- Ling Jin,
- Teng‐Fei Wan,
- Tao Yue,
- Si‐Yuan Tang,
- Hui Xie
Affiliations
- Yan Zhang
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Chun‐Yuan Chen
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Yi‐Wei Liu
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Shan‐Shan Rao
- Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China
- Yi‐Juan Tan
- Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China
- Yu‐Xuan Qian
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Kun Xia
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Jie Huang
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Xi‐Xi Liu
- Department of Neurology Xiangya Hospital Central South University Changsha Hunan 410013 China
- Chun‐Gu Hong
- Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China
- Hao Yin
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Jia Cao
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Shi‐Kai Feng
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Ze‐Hui He
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- You‐You Li
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Zhong‐Wei Luo
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Ben Wu
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Zi‐Qi Yan
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Tuan‐Hui Chen
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Meng‐Lu Chen
- Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China
- Yi‐Yi Wang
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Zhen‐Xing Wang
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Zheng‐Zhao Liu
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Ming‐Jie Luo
- Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China
- Xiong‐Ke Hu
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Ling Jin
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Teng‐Fei Wan
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Tao Yue
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- Si‐Yuan Tang
- Xiangya School of Nursing Central South University Changsha Hunan 410013 China
- Hui Xie
- Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China
- DOI
- https://doi.org/10.1002/advs.202100808
- Journal volume & issue
-
Vol. 8,
no. 24
pp. n/a – n/a
Abstract
Abstract A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age‐ and menopause‐associated bone loss and marrow adiposity. Here it is found that osteocytes, the most abundant bone cells, promote adipogenesis and inhibit osteogenesis of BMSCs by secreting neuropeptide Y (NPY), whose expression increases with aging and osteoporosis. Deletion of NPY in osteocytes generates a high bone mass phenotype, and attenuates aging‐ and ovariectomy (OVX)‐induced bone‐fat imbalance in mice. Osteocyte NPY production is under the control of autonomic nervous system (ANS) and osteocyte NPY deletion blocks the ANS‐induced regulation of BMSC fate and bone‐fat balance. γ‐Oryzanol, a clinically used ANS regulator, significantly increases bone formation and reverses aging‐ and OVX‐induced osteocyte NPY overproduction and marrow adiposity in control mice, but not in mice lacking osteocyte NPY. The study suggests a new mode of neuronal control of bone metabolism through the ANS‐induced regulation of osteocyte NPY.
Keywords
- adipogenesis
- autonomic nervous system
- bone marrow mesenchymal stem/stromal cells
- neuropeptide Y
- osteocyte
- osteogenesis
