Nature Communications (Aug 2019)
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway
- Joel C. Rosenbaum,
- Braulio Bonilla,
- Sarah R. Hengel,
- Tony M. Mertz,
- Benjamin W. Herken,
- Hinke G. Kazemier,
- Catherine A. Pressimone,
- Timothy C. Ratterman,
- Ellen MacNary,
- Alessio De Magis,
- Youngho Kwon,
- Stephen K. Godin,
- Bennett Van Houten,
- Daniel P. Normolle,
- Patrick Sung,
- Subha R. Das,
- Katrin Paeschke,
- Steven A. Roberts,
- Andrew P. VanDemark,
- Kara A. Bernstein
Affiliations
- Joel C. Rosenbaum
- University of Pittsburgh, Department of Biological Sciences Pittsburgh
- Braulio Bonilla
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- Sarah R. Hengel
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- Tony M. Mertz
- Washington State University, School of Molecular Biosciences and Center for Reproductive Biology, College of Veterinary Medicine
- Benjamin W. Herken
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- Hinke G. Kazemier
- University of Groningen, University Medical Center Groningen, European Research Institute for the Biology of Ageing
- Catherine A. Pressimone
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- Timothy C. Ratterman
- Carnegie Mellon University, Department of Chemistry and Center for Nucleic Acids Science & Technology
- Ellen MacNary
- Washington State University, School of Molecular Biosciences and Center for Reproductive Biology, College of Veterinary Medicine
- Alessio De Magis
- Department of Oncology, Hematology and Rheumatology, University Hospital Bonn
- Youngho Kwon
- Yale University, School of Medicine, Department of Molecular Biophysics and Biochemistry
- Stephen K. Godin
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- Bennett Van Houten
- University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology
- Daniel P. Normolle
- University of Pittsburgh, School of Public Health, Department of Biostatistics
- Patrick Sung
- Yale University, School of Medicine, Department of Molecular Biophysics and Biochemistry
- Subha R. Das
- Carnegie Mellon University, Department of Chemistry and Center for Nucleic Acids Science & Technology
- Katrin Paeschke
- University of Groningen, University Medical Center Groningen, European Research Institute for the Biology of Ageing
- Steven A. Roberts
- Washington State University, School of Molecular Biosciences and Center for Reproductive Biology, College of Veterinary Medicine
- Andrew P. VanDemark
- University of Pittsburgh, Department of Biological Sciences Pittsburgh
- Kara A. Bernstein
- University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics
- DOI
- https://doi.org/10.1038/s41467-019-11374-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.
