Millisecond dynamics of an unlabeled amino acid transporter

Tina R. Matin; George R. Heath; Gerard H. M. Huysmans; Olga Boudker; Simon Scheuring

doi:10.1038/s41467-020-18811-z

Nature Communications (Oct 2020)

Millisecond dynamics of an unlabeled amino acid transporter

Tina R. Matin,
George R. Heath,
Gerard H. M. Huysmans,
Olga Boudker,
Simon Scheuring

Affiliations

Tina R. Matin: Department of Anesthesiology, Weill Cornell Medicine
George R. Heath: Department of Anesthesiology, Weill Cornell Medicine
Gerard H. M. Huysmans: Department of Physiology and Biophysics, Weill Cornell Medicine
Olga Boudker: Department of Physiology and Biophysics, Weill Cornell Medicine
Simon Scheuring: Department of Anesthesiology, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s41467-020-18811-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Excitatory amino acid transporters (EAATs) are crucial for the removal of excitatory amino acids from the synaptic cleft. Here authors combined high-speed atomic force microscopy line-scanning with automated state assignment for the determination of transport dynamics of GltPh, a prokaryotic EAAT homologue, with millisecond temporal resolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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