Frontiers in Cardiovascular Medicine (May 2023)

Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review

  • Weimei Ou,
  • Bin Wang,
  • Guoming Zhang,
  • Licheng Ding,
  • Zhixian Liu,
  • Kaimin Wu,
  • Guangfeng Sun,
  • Chengmin Huang,
  • Zhaokai Li,
  • Shuyuan Feng,
  • Rui Gao

DOI
https://doi.org/10.3389/fcvm.2023.1123385
Journal volume & issue
Vol. 10

Abstract

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A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) is a kind of rare adverse event after COVID-19 vaccination. Herein, we present a case of an 83-year-old male who suffered cold sweat ten minutes after the first inactivated COVID-19 vaccination and AMI one day later. The emergency coronary angiography showed coronary thrombosis and underlying stenosis in his coronary artery. Type II Kounis syndrome might be a potential mechanism, which is manifested as coronary thrombosis secondary to allergic reactions in patients with underlying asymptomatic coronary heart disease. We also summarize the reported AMI cases post COVID-19 vaccination, as well as overview and discuss the proposed mechanisms of AMI after COVID-19 vaccination, thus providing insights for clinicians to be aware of the possibility of AMI following COVID-19 vaccination and potential underlying mechanisms.

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