Nature Communications (Feb 2021)
Discrete SARS-CoV-2 antibody titers track with functional humoral stability
- Yannic C. Bartsch,
- Stephanie Fischinger,
- Sameed M. Siddiqui,
- Zhilin Chen,
- Jingyou Yu,
- Makda Gebre,
- Caroline Atyeo,
- Matthew J. Gorman,
- Alex Lee Zhu,
- Jaewon Kang,
- John S. Burke,
- Matthew Slein,
- Matthew J. Gluck,
- Samuel Beger,
- Yiyuan Hu,
- Justin Rhee,
- Eric Petersen,
- Benjamin Mormann,
- Michael de St Aubin,
- Mohammad A. Hasdianda,
- Guruprasad Jambaulikar,
- Edward W. Boyer,
- Pardis C. Sabeti,
- Dan H. Barouch,
- Boris D. Julg,
- Elon R. Musk,
- Anil S. Menon,
- Douglas A. Lauffenburger,
- Eric J. Nilles,
- Galit Alter
Affiliations
- Yannic C. Bartsch
- Ragon Institute of MGH, MIT and Harvard
- Stephanie Fischinger
- Ragon Institute of MGH, MIT and Harvard
- Sameed M. Siddiqui
- Computational and Systems Biology Program, Massachusetts Institute of Technology
- Zhilin Chen
- Ragon Institute of MGH, MIT and Harvard
- Jingyou Yu
- Ragon Institute of MGH, MIT and Harvard
- Makda Gebre
- Ragon Institute of MGH, MIT and Harvard
- Caroline Atyeo
- Ragon Institute of MGH, MIT and Harvard
- Matthew J. Gorman
- Ragon Institute of MGH, MIT and Harvard
- Alex Lee Zhu
- Ragon Institute of MGH, MIT and Harvard
- Jaewon Kang
- Ragon Institute of MGH, MIT and Harvard
- John S. Burke
- Ragon Institute of MGH, MIT and Harvard
- Matthew Slein
- Ragon Institute of MGH, MIT and Harvard
- Matthew J. Gluck
- Space Exploration Technologies Corp
- Samuel Beger
- Space Exploration Technologies Corp
- Yiyuan Hu
- Space Exploration Technologies Corp
- Justin Rhee
- Space Exploration Technologies Corp
- Eric Petersen
- Space Exploration Technologies Corp
- Benjamin Mormann
- Space Exploration Technologies Corp
- Michael de St Aubin
- Harvard Humanitarian Initiative
- Mohammad A. Hasdianda
- Brigham and Women’s Hospital
- Guruprasad Jambaulikar
- Brigham and Women’s Hospital
- Edward W. Boyer
- Brigham and Women’s Hospital
- Pardis C. Sabeti
- Broad Institute of MIT and Harvard
- Dan H. Barouch
- Ragon Institute of MGH, MIT and Harvard
- Boris D. Julg
- Ragon Institute of MGH, MIT and Harvard
- Elon R. Musk
- Space Exploration Technologies Corp
- Anil S. Menon
- Space Exploration Technologies Corp
- Douglas A. Lauffenburger
- Department of Biological Engineering, Massachusetts Institute of Technology
- Eric J. Nilles
- Brigham and Women’s Hospital
- Galit Alter
- Ragon Institute of MGH, MIT and Harvard
- DOI
- https://doi.org/10.1038/s41467-021-21336-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.
