CD36-mediated podocyte lipotoxicity promotes foot process effacement

Abstract

Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte lipotoxicity.

Keywords

• cd36
• podocyte
• foot process effacement
• palmitic acid
• ros