Open Medicine
(Mar 2024)
CD36-mediated podocyte lipotoxicity promotes foot process effacement
Hua Wei,
Peng Lan,
Chen Xue-mei,
Jiang XuShun,
Hu JianGuo,
Jiang Xian-Hong,
Xiang Xu,
Wan Jiangmin,
Long Yingfei,
Xiong Jianqiong,
Ma Xueyi,
Du Xiaogang
Affiliations
Hua Wei
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing400000, China
Peng Lan
Basic Department, Chongqing Medical and Pharmaceutical College, Chongqing401331, China
Chen Xue-mei
Emergency Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing400042, China
Jiang XuShun
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing400042, China
Hu JianGuo
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
Jiang Xian-Hong
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing400000, China
Xiang Xu
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing400000, China
Wan Jiangmin
Department of Nephrology, People’s Hospital of Qijiang District, Chongqing401420, China
Long Yingfei
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China
Xiong Jianqiong
Hospital of Chongqing University, Chongqing, 400044, China
Ma Xueyi
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing400000, China
Du Xiaogang
Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing 400042, China
DOI
https://doi.org/10.1515/med-2024-0918
Journal volume & issue
Vol. 19,
no. 1
Abstract
Read online
Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte lipotoxicity.
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