Nature Communications (May 2016)
Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese
- Yuanfeng Li,
- Lanlan Si,
- Yun Zhai,
- Yanling Hu,
- Zhibin Hu,
- Jin-Xin Bei,
- Bobo Xie,
- Qian Ren,
- Pengbo Cao,
- Fei Yang,
- Qingfeng Song,
- Zhiyu Bao,
- Haitao Zhang,
- Yuqing Han,
- Zhifu Wang,
- Xi Chen,
- Xia Xia,
- Hongbo Yan,
- Rui Wang,
- Ying Zhang,
- Chengming Gao,
- Jinfeng Meng,
- Xinyi Tu,
- Xinqiang Liang,
- Ying Cui,
- Ying Liu,
- Xiaopan Wu,
- Zhuo Li,
- Huifen Wang,
- Zhaoxia Li,
- Bo Hu,
- Minghui He,
- Zhibo Gao,
- Xiaobing Xu,
- Hongzan Ji,
- Chaohui Yu,
- Yi Sun,
- Baocai Xing,
- Xiaobo Yang,
- Haiying Zhang,
- Aihua Tan,
- Chunlei Wu,
- Weihua Jia,
- Shengping Li,
- Yi-Xin Zeng,
- Hongbing Shen,
- Fuchu He,
- Zengnan Mo,
- Hongxing Zhang,
- Gangqiao Zhou
Affiliations
- Yuanfeng Li
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Lanlan Si
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Yun Zhai
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Yanling Hu
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Zhibin Hu
- Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University
- Jin-Xin Bei
- State Key Laboratory of Oncology in Southern China
- Bobo Xie
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Qian Ren
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Pengbo Cao
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Fei Yang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Qingfeng Song
- Affiliated Cancer Hospital of Guangxi Medical University
- Zhiyu Bao
- Affiliated Cancer Hospital of Guangxi Medical University
- Haitao Zhang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Yuqing Han
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Zhifu Wang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Xi Chen
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Xia Xia
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Hongbo Yan
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Rui Wang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Ying Zhang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Chengming Gao
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Jinfeng Meng
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Xinyi Tu
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Xinqiang Liang
- Affiliated Cancer Hospital of Guangxi Medical University
- Ying Cui
- Affiliated Cancer Hospital of Guangxi Medical University
- Ying Liu
- National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
- Xiaopan Wu
- National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
- Zhuo Li
- Department of Infectious Disease, Affiliated You’an Hospital, Capital University of Medical Science
- Huifen Wang
- Liver Failure Treatment and Research Center
- Zhaoxia Li
- Department of Clinical Laboratory, the Third Affiliated Hospital, Sun Yat-sen University
- Bo Hu
- Department of Clinical Laboratory, the Third Affiliated Hospital, Sun Yat-sen University
- Minghui He
- BGI-Shenzhen
- Zhibo Gao
- BGI-Shenzhen
- Xiaobing Xu
- Department of Gastroenterology and Hepatology, Jinling Hospital, Clinical School of Nanjing University
- Hongzan Ji
- Department of Gastroenterology and Hepatology, Jinling Hospital, Clinical School of Nanjing University
- Chaohui Yu
- Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University
- Yi Sun
- Department of Hepatobiliary Surgery I, Peking University Cancer Hospital and Institute
- Baocai Xing
- Department of Hepatobiliary Surgery I, Peking University Cancer Hospital and Institute
- Xiaobo Yang
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Haiying Zhang
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Aihua Tan
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Chunlei Wu
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Weihua Jia
- State Key Laboratory of Oncology in Southern China
- Shengping Li
- State Key Laboratory of Oncology in Southern China
- Yi-Xin Zeng
- State Key Laboratory of Oncology in Southern China
- Hongbing Shen
- Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University
- Fuchu He
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Zengnan Mo
- Center for Genomic and Personalized Medicine, Guangxi Medical University
- Hongxing Zhang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- Gangqiao Zhou
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine
- DOI
- https://doi.org/10.1038/ncomms11664
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
This genome-wide association study on persistent hepatitis B virus (HBV) infection among Chinese confirms previously associated genetic loci while discovering a novel protective locus at 8p21.3. The study also demonstrates the nearby gene INST10 suppresses HBV replication in vitro.
