Bromopyrrole Alkaloids from the Sponge <em>Agelas kosrae</em>
Oh-Seok Kwon,
Donghwa Kim,
Heegyu Kim,
Yeon-Ju Lee,
Hyi-Seung Lee,
Chung J. Sim,
Dong-Chan Oh,
Sang Kook Lee,
Ki-Bong Oh,
Jongheon Shin
Affiliations
Oh-Seok Kwon
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
Donghwa Kim
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
Heegyu Kim
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
Yeon-Ju Lee
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea
Hyi-Seung Lee
Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, P.O. Box 29, Seoul 425-600, Korea
Chung J. Sim
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
Dong-Chan Oh
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
Sang Kook Lee
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
Ki-Bong Oh
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
Jongheon Shin
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.
