Biological Psychiatry Global Open Science (Apr 2022)
Identifying the Common Genetic Basis of Antidepressant Response
- Oliver Pain,
- Karen Hodgson,
- Vassily Trubetskoy,
- Stephan Ripke,
- Victoria S. Marshe,
- Mark J. Adams,
- Enda M. Byrne,
- Adrian I. Campos,
- Tania Carrillo-Roa,
- Annamaria Cattaneo,
- Thomas D. Als,
- Daniel Souery,
- Mojca Z. Dernovsek,
- Chiara Fabbri,
- Caroline Hayward,
- Neven Henigsberg,
- Joanna Hauser,
- James L. Kennedy,
- Eric J. Lenze,
- Glyn Lewis,
- Daniel J. Müller,
- Nicholas G. Martin,
- Benoit H. Mulsant,
- Ole Mors,
- Nader Perroud,
- David J. Porteous,
- Miguel E. Rentería,
- Charles F. Reynolds, III,
- Marcella Rietschel,
- Rudolf Uher,
- Eleanor M. Wigmore,
- Wolfgang Maier,
- Naomi R. Wray,
- Katherine J. Aitchison,
- Volker Arolt,
- Bernhard T. Baune,
- Joanna M. Biernacka,
- Guido Bondolfi,
- Katharina Domschke,
- Masaki Kato,
- Qingqin S. Li,
- Yu-Li Liu,
- Alessandro Serretti,
- Shih-Jen Tsai,
- Gustavo Turecki,
- Richard Weinshilboum,
- Andrew M. McIntosh,
- Cathryn M. Lewis,
- Siegfried Kasper,
- Joseph Zohar,
- Daniel Souery,
- Stuart Montgomery,
- Diego Albani,
- Gianluigi Forloni,
- Panagiotis Ferentinos,
- Dan Rujescu,
- Julien Mendlewicz,
- Naomi R. Wray,
- Stephan Ripke,
- Manuel Mattheisen,
- Maciej Trzaskowski,
- Enda M. Byrne,
- Abdel Abdellaoui,
- Mark J. Adams,
- Esben Agerbo,
- Tracy M. Air,
- Till F.M. Andlauer,
- Silviu-Alin Bacanu,
- Marie Bækvad-Hansen,
- Aartjan T.F. Beekman,
- Tim B. Bigdeli,
- Elisabeth B. Binder,
- Julien Bryois,
- Henriette N. Buttenschøn,
- Jonas Bybjerg-Grauholm,
- Na Cai,
- Enrique Castelao,
- Jane Hvarregaard Christensen,
- Toni-Kim Clarke,
- Jonathan R.I. Coleman,
- Lucía Colodro-Conde,
- Baptiste Couvy-Duchesne,
- Nick Craddock,
- Gregory E. Crawford,
- Gail Davies,
- Ian J. Deary,
- Franziska Degenhardt,
- Eske M. Derks,
- Nese Direk,
- Conor V. Dolan,
- Erin C. Dunn,
- Thalia C. Eley,
- Valentina Escott-Price,
- Farnush Farhadi Hassan Kiadeh,
- Hilary K. Finucane,
- Jerome C. Foo,
- Andreas J. Forstner,
- Josef Frank,
- Héléna A. Gaspar,
- Michael Gill,
- Fernando S. Goes,
- Scott D. Gordon,
- Jakob Grove,
- Lynsey S. Hall,
- Christine Søholm Hansen,
- Thomas F. Hansen,
- Stefan Herms,
- Ian B. Hickie,
- Per Hoffmann,
- Georg Homuth,
- Carsten Horn,
- Jouke-Jan Hottenga,
- David M. Hougaard,
- David M. Howard,
- Marcus Ising,
- Rick Jansen,
- Ian Jones,
- Lisa A. Jones,
- Eric Jorgenson,
- James A. Knowles,
- Isaac S. Kohane,
- Julia Kraft,
- Warren W. Kretzschmar,
- Zoltán Kutalik,
- Yihan Li,
- Penelope A. Lind,
- Donald J. MacIntyre,
- Dean F. MacKinnon,
- Robert M. Maier,
- Wolfgang Maier,
- Jonathan Marchini,
- Hamdi Mbarek,
- Patrick McGrath,
- Peter McGuffin,
- Sarah E. Medland,
- Divya Mehta,
- Christel M. Middeldorp,
- Evelin Mihailov,
- Yuri Milaneschi,
- Lili Milani,
- Francis M. Mondimore,
- Grant W. Montgomery,
- Sara Mostafavi,
- Niamh Mullins,
- Matthias Nauck,
- Bernard Ng,
- Michel G. Nivard,
- Dale R. Nyholt,
- Paul F. O’Reilly,
- Hogni Oskarsson,
- Michael J. Owen,
- Jodie N. Painter,
- Carsten Bøcker Pedersen,
- Marianne Giørtz Pedersen,
- Roseann E. Peterson,
- Wouter J. Peyrot,
- Giorgio Pistis,
- Danielle Posthuma,
- Jorge A. Quiroz,
- Per Qvist,
- John P. Rice,
- Brien P. Riley,
- Margarita Rivera,
- Saira Saeed Mirza,
- Robert Schoevers,
- Eva C. Schulte,
- Ling Shen,
- Jianxin Shi,
- Stanley I. Shyn,
- Engilbert Sigurdsson,
- Grant C.B. Sinnamon,
- Johannes H. Smit,
- Daniel J. Smith,
- Hreinn Stefansson,
- Stacy Steinberg,
- Fabian Streit,
- Jana Strohmaier,
- Katherine E. Tansey,
- Henning Teismann,
- Alexander Teumer,
- Wesley Thompson,
- Pippa A. Thomson,
- Thorgeir E. Thorgeirsson,
- Matthew Traylor,
- Jens Treutlein,
- Vassily Trubetskoy,
- André G. Uitterlinden,
- Daniel Umbricht,
- Sandra Van der Auwera,
- Albert M. van Hemert,
- Alexander Viktorin,
- Peter M. Visscher,
- Yunpeng Wang,
- Bradley T. Webb,
- Shantel Marie Weinsheimer,
- Jürgen Wellmann,
- Gonneke Willemsen,
- Stephanie H. Witt,
- Yang Wu,
- Hualin S. Xi,
- Jian Yang,
- Futao Zhang,
- Volker Arolt,
- Bernhard T. Baune,
- Klaus Berger,
- Dorret I. Boomsma,
- Sven Cichon,
- Udo Dannlowski,
- E.J.C. de Geus,
- J. Raymond DePaulo,
- Enrico Domenici,
- Katharina Domschke,
- Tõnu Esko,
- Hans J. Grabe,
- Steven P. Hamilton,
- Caroline Hayward,
- Andrew C. Heath,
- Kenneth S. Kendler,
- Stefan Kloiber,
- Glyn Lewis,
- Qingqin S. Li,
- Susanne Lucae,
- Pamela A.F. Madden,
- Patrik K. Magnusson,
- Nicholas G. Martin,
- Andrew M. McIntosh,
- Andres Metspalu,
- Ole Mors,
- Preben Bo Mortensen,
- Bertram Müller-Myhsok,
- Merete Nordentoft,
- Markus M. Nöthen,
- Michael C. O’Donovan,
- Sara A. Paciga,
- Nancy L. Pedersen,
- Brenda W.J.H. Penninx,
- Roy H. Perlis,
- David J. Porteous,
- James B. Potash,
- Martin Preisig,
- Marcella Rietschel,
- Catherine Schaefer,
- Thomas G. Schulze,
- Jordan W. Smoller,
- Kari Stefansson,
- Henning Tiemeier,
- Rudolf Uher,
- Henry Völzke,
- Myrna M. Weissman,
- Thomas Werge,
- Cathryn M. Lewis,
- Douglas F. Levinson,
- Gerome Breen,
- Anders D. Børglum,
- Patrick F. Sullivan
Affiliations
- Oliver Pain
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom; Address correspondence to Oliver Pain, Ph.D.
- Karen Hodgson
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom
- Vassily Trubetskoy
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany
- Stephan Ripke
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts
- Victoria S. Marshe
- Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
- Mark J. Adams
- Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- Enda M. Byrne
- Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
- Adrian I. Campos
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
- Tania Carrillo-Roa
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
- Annamaria Cattaneo
- Biological Psychiatry Laboratory, IRCCS Fatebenefratelli, Brescia, Italy
- Thomas D. Als
- Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, Aarhus, Denmark; Department of Biomedicine and Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, Central Region Denmark and Aarhus University, Aarhus, Denmark
- Daniel Souery
- Laboratoire de Psychologie Medicale, Université Libre de Bruxelles, Brussels, Belgium; Centre Européen de Psychologie Medicale (PsyPluriel), Brussels, Belgium
- Mojca Z. Dernovsek
- University Psychiatric Clinic, University of Ljubliana, Ljubljana, Slovakia
- Chiara Fabbri
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom
- Caroline Hayward
- MRC Human Genetics Unit, University of Edinburgh, Edinburgh, United Kingdom
- Neven Henigsberg
- Department of Psychiatry, Croatian Institute for Brain Research, University of Zagreb Medical School, Zagreb, Croatia
- Joanna Hauser
- Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland
- James L. Kennedy
- Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
- Eric J. Lenze
- Healthy Mind Lab, Washington University School of Medicine in St. Louis, St. Louis, Missouri
- Glyn Lewis
- Division of Psychiatry, University College London, London, United Kingdom
- Daniel J. Müller
- Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
- Nicholas G. Martin
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
- Benoit H. Mulsant
- Division of Adult Neurodevelopment and Geriatric Psychiatry, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
- Ole Mors
- Psychosis Research Unit, Aarhus University Hospital – Psychiatry, Aarhus, Denmark
- Nader Perroud
- Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland
- David J. Porteous
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
- Miguel E. Rentería
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
- Charles F. Reynolds, III
- Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
- Marcella Rietschel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Heidelberg University Faculty of Medicine in Mannheim, Mannheim, Germany
- Rudolf Uher
- Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
- Eleanor M. Wigmore
- Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- Wolfgang Maier
- Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
- Naomi R. Wray
- Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
- Katherine J. Aitchison
- Department of Psychiatry, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada; Department of Medical Genetics, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada
- Volker Arolt
- Department of Psychiatry, University of Münster, Münster, Germany
- Bernhard T. Baune
- Department of Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
- Joanna M. Biernacka
- Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
- Guido Bondolfi
- Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland
- Katharina Domschke
- Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Freiburg, Germany
- Masaki Kato
- Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
- Qingqin S. Li
- Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, New Jersey
- Yu-Li Liu
- Center for Neuropsychiatric Research, National Health Research Institutes, Zhunan, Taipei, Taiwan
- Alessandro Serretti
- Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
- Shih-Jen Tsai
- Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Gustavo Turecki
- Department of Psychiatry, Douglas Institute, McGill University, Montreal, Quebec, Canada
- Richard Weinshilboum
- Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota
- Andrew M. McIntosh
- Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- Cathryn M. Lewis
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom; Department of Medical and Molecular Genetics, King’s College London, London, United Kingdom
- Siegfried Kasper
- Department of Psychiatry and Psychotherapy, Medical University Vienna, Austria
- Joseph Zohar
- Department of Psychiatry, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Israel
- Daniel Souery
- Laboratoire de Psychologie Médicale, Université Libre de Bruxelles and Psy Pluriel, Centre Européen de Psychologie Médicale, Brussels
- Stuart Montgomery
- Imperial College School of Medicine, London, UK
- Diego Albani
- Laboratory of Biology of Neurodegenerative Disorders, Neuroscience Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
- Gianluigi Forloni
- Laboratory of Biology of Neurodegenerative Disorders, Neuroscience Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
- Panagiotis Ferentinos
- Department of Psychiatry, Athens University Medical School, Athens, Greece
- Dan Rujescu
- University Clinic for Psychiatry, Psychotherapy and Psychosomatic, Martin-Luther-University Halle-Wittenberg, Germany
- Julien Mendlewicz
- Université Libre de Bruxelles
- Naomi R. Wray
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Stephan Ripke
- Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, US; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, DE; Medical and Population Genetics, Broad Institute, Cambridge, MA, US
- Manuel Mattheisen
- Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, DE; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SE; Department of Biomedicine, Aarhus University, Aarhus, DK
- Maciej Trzaskowski
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Enda M. Byrne
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Abdel Abdellaoui
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Mark J. Adams
- Division of Psychiatry, University of Edinburgh, Edinburgh, GB
- Esben Agerbo
- Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK; National Centre for Register-Based Research, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Tracy M. Air
- Discipline of Psychiatry, University of Adelaide, Adelaide, SA, AU
- Till F.M. Andlauer
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, DE
- Silviu-Alin Bacanu
- Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US
- Marie Bækvad-Hansen
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Aartjan T.F. Beekman
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Tim B. Bigdeli
- Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US; Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, US
- Elisabeth B. Binder
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, US
- Julien Bryois
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Henriette N. Buttenschøn
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- Jonas Bybjerg-Grauholm
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Na Cai
- Human Genetics, Wellcome Trust Sanger Institute, Cambridge, GB; Statistical genomics and systems genetics, European Bioinformatics Institute (EMBL-EBI), Cambridge, GB
- Enrique Castelao
- Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, CH
- Jane Hvarregaard Christensen
- Department of Biomedicine, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- Toni-Kim Clarke
- Division of Psychiatry, University of Edinburgh, Edinburgh, GB
- Jonathan R.I. Coleman
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Lucía Colodro-Conde
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Baptiste Couvy-Duchesne
- Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, AU
- Nick Craddock
- Psychological Medicine, Cardiff University, Cardiff, GB
- Gregory E. Crawford
- Center for Genomic and Computational Biology, Duke University, Durham, NC, US; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, US
- Gail Davies
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, GB
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, GB
- Franziska Degenhardt
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE
- Eske M. Derks
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Nese Direk
- Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, NL; Psychiatry, Dokuz Eylul University School Of Medicine, Izmir, TR
- Conor V. Dolan
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Erin C. Dunn
- Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, US; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Thalia C. Eley
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Valentina Escott-Price
- Neuroscience and Mental Health, Cardiff University, Cardiff, GB
- Farnush Farhadi Hassan Kiadeh
- Bioinformatics, University of British Columbia, Vancouver, BC, CA
- Hilary K. Finucane
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, US; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, US
- Jerome C. Foo
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Andreas J. Forstner
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE; Department of Psychiatry (UPK), University of Basel, Basel, CH; Department of Biomedicine, University of Basel, Basel, CH; Centre for Human Genetics, University of Marburg, Marburg, DE
- Josef Frank
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Héléna A. Gaspar
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Michael Gill
- Department of Psychiatry, Trinity College Dublin, Dublin, IE
- Fernando S. Goes
- Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MD, US
- Scott D. Gordon
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Jakob Grove
- Department of Biomedicine, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK; Bioinformatics Research Centre, Aarhus University, Aarhus, DK
- Lynsey S. Hall
- Division of Psychiatry, University of Edinburgh, Edinburgh, GB; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, GB
- Christine Søholm Hansen
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- Thomas F. Hansen
- Danish Headache Centre, Department of Neurology, Rigshospitalet, Glostrup, DK; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, DK; iPSYCH, The Lundbeck Foundation Initiative for Psychiatric Research, Copenhagen, DK
- Stefan Herms
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE; Department of Biomedicine, University of Basel, Basel, CH
- Ian B. Hickie
- Brain and Mind Centre, University of Sydney, Sydney, NSW, AU
- Per Hoffmann
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE; Department of Biomedicine, University of Basel, Basel, CH
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Carsten Horn
- Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, CH
- Jouke-Jan Hottenga
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- David M. Hougaard
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK
- David M. Howard
- Division of Psychiatry, University of Edinburgh, Edinburgh, GB; Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Marcus Ising
- Max Planck Institute of Psychiatry, Munich, DE
- Rick Jansen
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Ian Jones
- MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, GB
- Lisa A. Jones
- Department of Psychological Medicine, University of Worcester, Worcester, GB
- Eric Jorgenson
- Division of Research, Kaiser Permanente Northern California, Oakland, CA, US
- James A. Knowles
- Psychiatry & The Behavioral Sciences, University of Southern California, Los Angeles, CA, US
- Isaac S. Kohane
- Department of Biomedical Informatics, Harvard Medical School, Boston, MA, US; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, US; Informatics Program, Boston Children’s Hospital, Boston, MA, US
- Julia Kraft
- Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, DE
- Warren W. Kretzschmar
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, GB
- Zoltán Kutalik
- Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Lausanne, VD, CH; Swiss Institute of Bioinformatics, Lausanne, VD, CH
- Yihan Li
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, GB
- Penelope A. Lind
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Donald J. MacIntyre
- Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, GB; Mental Health, NHS 24, Glasgow, GB
- Dean F. MacKinnon
- Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MD, US
- Robert M. Maier
- Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Wolfgang Maier
- Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, DE
- Jonathan Marchini
- Statistics, University of Oxford, Oxford, GB
- Hamdi Mbarek
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Patrick McGrath
- Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, US
- Peter McGuffin
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Sarah E. Medland
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Divya Mehta
- Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU; School of Psychology and Counseling, Queensland University of Technology, Brisbane, QLD, AU
- Christel M. Middeldorp
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL; Child and Youth Mental Health Service, Children’s Health Queensland Hospital and Health Service, South Brisbane, QLD, AU; Child Health Research Centre, University of Queensland, Brisbane, QLD, AU
- Evelin Mihailov
- Estonian Genome Center, University of Tartu, Tartu, EE
- Yuri Milaneschi
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Lili Milani
- Estonian Genome Center, University of Tartu, Tartu, EE
- Francis M. Mondimore
- Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MD, US
- Grant W. Montgomery
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Sara Mostafavi
- Medical Genetics, University of British Columbia, Vancouver, BC, CA; Statistics, University of British Columbia, Vancouver, BC, CA
- Niamh Mullins
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Matthias Nauck
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Bernard Ng
- Statistics, University of British Columbia, Vancouver, BC, CA
- Michel G. Nivard
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Dale R. Nyholt
- Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AU
- Paul F. O’Reilly
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB
- Hogni Oskarsson
- Humus, Reykjavik, IS
- Michael J. Owen
- MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, GB
- Jodie N. Painter
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Carsten Bøcker Pedersen
- Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK; National Centre for Register-Based Research, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Marianne Giørtz Pedersen
- Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK; National Centre for Register-Based Research, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK
- Roseann E. Peterson
- Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US; Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, US
- Wouter J. Peyrot
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Giorgio Pistis
- Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, CH
- Danielle Posthuma
- Clinical Genetics, Vrije Universiteit Medical Center, Amsterdam, NL; Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, NL
- Jorge A. Quiroz
- Solid Biosciences, Boston, MA, US
- Per Qvist
- Department of Biomedicine, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- John P. Rice
- Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, US
- Brien P. Riley
- Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US
- Margarita Rivera
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB; Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Biomedical Research Center (CIBM), University of Granada, Granada, ES
- Saira Saeed Mirza
- Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, NL
- Robert Schoevers
- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, NL
- Eva C. Schulte
- Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University Munich, Munich, DE; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University Munich, Munich, DE
- Ling Shen
- Division of Research, Kaiser Permanente Northern California, Oakland, CA, US
- Jianxin Shi
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, US
- Stanley I. Shyn
- Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, US
- Engilbert Sigurdsson
- Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, IS
- Grant C.B. Sinnamon
- School of Medicine and Dentistry, James Cook University, Townsville, QLD, AU
- Johannes H. Smit
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Daniel J. Smith
- Institute of Health and Wellbeing, University of Glasgow, Glasgow, GB
- Hreinn Stefansson
- deCODE Genetics / Amgen, Reykjavik, IS
- Stacy Steinberg
- deCODE Genetics / Amgen, Reykjavik, IS
- Fabian Streit
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Jana Strohmaier
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Katherine E. Tansey
- College of Biomedical and Life Sciences, Cardiff University, Cardiff, GB
- Henning Teismann
- Institute of Epidemiology and Social Medicine, University of Münster, Münster, Nordrhein-Westfalen, DE
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Wesley Thompson
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, DK; Department of Psychiatry, University of California, San Diego, San Diego, CA, US; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- Pippa A. Thomson
- Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, GB
- Thorgeir E. Thorgeirsson
- deCODE Genetics / Amgen, Reykjavik, IS
- Matthew Traylor
- Clinical Neurosciences, University of Cambridge, Cambridge, GB
- Jens Treutlein
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Vassily Trubetskoy
- Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, DE
- André G. Uitterlinden
- Internal Medicine, Erasmus MC, Rotterdam, Zuid-Holland, NL
- Daniel Umbricht
- Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery & Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, CH
- Sandra Van der Auwera
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Albert M. van Hemert
- Department of Psychiatry, Leiden University Medical Center, Leiden, NL
- Alexander Viktorin
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Peter M. Visscher
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Yunpeng Wang
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, DK; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NO
- Bradley T. Webb
- Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, US
- Shantel Marie Weinsheimer
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, DK
- Jürgen Wellmann
- Institute of Epidemiology and Social Medicine, University of Münster, Münster, Nordrhein-Westfalen, DE
- Gonneke Willemsen
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Stephanie H. Witt
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Yang Wu
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Hualin S. Xi
- Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, US
- Jian Yang
- Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU; Institute for Molecular Bioscience Queensland Brain Institute, The University of Queensland, Brisbane, QLD, AU
- Futao Zhang
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, AU
- Volker Arolt
- Department of Psychiatry, University of Münster, Münster, Nordrhein-Westfalen, DE
- Bernhard T. Baune
- Department of Psychiatry, University of Münster, Münster, Nordrhein-Westfalen, DE; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, AU; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, AU
- Klaus Berger
- Institute of Epidemiology and Social Medicine, University of Münster, Münster, Nordrhein-Westfalen, DE
- Dorret I. Boomsma
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL
- Sven Cichon
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE; Department of Biomedicine, University of Basel, Basel, CH; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, CH; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, DE
- Udo Dannlowski
- Department of Psychiatry, University of Münster, Münster, Nordrhein-Westfalen, DE
- E.J.C. de Geus
- Dept of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, NL; Amsterdam Public Health Institute, Vrije Universiteit Medical Center, Amsterdam, NL
- J. Raymond DePaulo
- Psychiatry & Behavioral Sciences, Johns Hopkins University, Baltimore, MD, US
- Enrico Domenici
- Centre for Integrative Biology, Università degli Studi di Trento, Trento, Trentino-Alto Adige, IT
- Katharina Domschke
- Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, DE; Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, DE
- Tõnu Esko
- Medical and Population Genetics, Broad Institute, Cambridge, MA, US; Estonian Genome Center, University of Tartu, Tartu, EE
- Hans J. Grabe
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Steven P. Hamilton
- Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, US
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, GB
- Andrew C. Heath
- Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, US
- Kenneth S. Kendler
- Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US
- Stefan Kloiber
- Max Planck Institute of Psychiatry, Munich, DE; Department of Psychiatry, University of Toronto, Toronto, ON, CA; Centre for Addiction and Mental Health, Toronto, ON, CA
- Glyn Lewis
- Division of Psychiatry, University College London, London, GB
- Qingqin S. Li
- Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, US
- Susanne Lucae
- Max Planck Institute of Psychiatry, Munich, DE
- Pamela A.F. Madden
- Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, US
- Patrik K. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Nicholas G. Martin
- Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AU
- Andrew M. McIntosh
- Division of Psychiatry, University of Edinburgh, Edinburgh, GB; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, GB
- Andres Metspalu
- Estonian Genome Center, University of Tartu, Tartu, EE; Institute of Molecular and Cell Biology, University of Tartu, Tartu, EE
- Ole Mors
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, DK
- Preben Bo Mortensen
- Centre for Integrated Register-based Research, Aarhus University, Aarhus, DK; National Centre for Register-Based Research, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- Bertram Müller-Myhsok
- Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, DE; Munich Cluster for Systems Neurology (SyNergy), Munich, DE; University of Liverpool, Liverpool, GB
- Merete Nordentoft
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Mental Health Center Copenhagen, Copenhagen Universtity Hospital, Copenhagen, DK
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, DE
- Michael C. O’Donovan
- MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, GB
- Sara A. Paciga
- Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, US
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE
- Brenda W.J.H. Penninx
- Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, NL
- Roy H. Perlis
- Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US; Psychiatry, Harvard Medical School, Boston, MA, US
- David J. Porteous
- Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, GB
- James B. Potash
- Psychiatry, University of Iowa, Iowa City, IA, US
- Martin Preisig
- Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, CH
- Marcella Rietschel
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE
- Catherine Schaefer
- Division of Research, Kaiser Permanente Northern California, Oakland, CA, US
- Thomas G. Schulze
- Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, DE; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University Munich, Munich, DE; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, US; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Goettingen, Niedersachsen, DE; Human Genetics Branch, NIMH Division of Intramural Research Programs, Bethesda, MD, US
- Jordan W. Smoller
- Department of Psychiatry, Massachusetts General Hospital, Boston, MA, US; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, US; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, US
- Kari Stefansson
- deCODE Genetics / Amgen, Reykjavik, IS; Faculty of Medicine, University of Iceland, Reykjavik, IS
- Henning Tiemeier
- Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, NL; Child and Adolescent Psychiatry, Erasmus MC, Rotterdam, Zuid-Holland, NL; Psychiatry, Erasmus MC, Rotterdam, Zuid-Holland, NL
- Rudolf Uher
- Psychiatry, Dalhousie University, Halifax, NS, CA
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, DE
- Myrna M. Weissman
- Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, US; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, NY, US
- Thomas Werge
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, DK; Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK
- Cathryn M. Lewis
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB; Department of Medical & Molecular Genetics, King’s College London, London, GB
- Douglas F. Levinson
- Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, US
- Gerome Breen
- Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, GB; NIHR Maudsley Biomedical Research Centre, King’s College London, London, GB
- Anders D. Børglum
- Department of Biomedicine, Aarhus University, Aarhus, DK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, DK; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK
- Patrick F. Sullivan
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, US; Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
- Journal volume & issue
-
Vol. 2,
no. 2
pp. 115 – 126
Abstract
Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous genome-wide association studies has been limited by sample size. This study performs the largest genetic analysis of prospectively assessed antidepressant response in major depressive disorder to gain insight into the underlying biology and enable out-of-sample prediction. Methods: Genome-wide analysis of remission (nremit = 1852, nnonremit = 3299) and percentage improvement (n = 5218) was performed. Single nucleotide polymorphism–based heritability was estimated using genome-wide complex trait analysis. Genetic covariance with eight mental health phenotypes was estimated using polygenic scores/AVENGEME. Out-of-sample prediction of antidepressant response polygenic scores was assessed. Gene-level association analysis was performed using MAGMA and transcriptome-wide association study. Tissue, pathway, and drug binding enrichment were estimated using MAGMA. Results: Neither genome-wide association study identified genome-wide significant associations. Single nucleotide polymorphism–based heritability was significantly different from zero for remission (h2 = 0.132, SE = 0.056) but not for percentage improvement (h2 = −0.018, SE = 0.032). Better antidepressant response was negatively associated with genetic risk for schizophrenia and positively associated with genetic propensity for educational attainment. Leave-one-out validation of antidepressant response polygenic scores demonstrated significant evidence of out-of-sample prediction, though results varied in external cohorts. Gene-based analyses identified ETV4 and DHX8 as significantly associated with antidepressant response. Conclusions: This study demonstrates that antidepressant response is influenced by common genetic variation, has a genetic overlap schizophrenia and educational attainment, and provides a useful resource for future research. Larger sample sizes are required to attain the potential of genetics for understanding and predicting antidepressant response.
