Anionic phospholipids control mechanisms of GPCR-G protein recognition

Naveen Thakur; Arka P. Ray; Liam Sharp; Beining Jin; Alexander Duong; Niloofar Gopal Pour; Samuel Obeng; Anuradha V. Wijesekara; Zhan-Guo Gao; Christopher R. McCurdy; Kenneth A. Jacobson; Edward Lyman; Matthew T. Eddy

doi:10.1038/s41467-023-36425-z

Nature Communications (Feb 2023)

Anionic phospholipids control mechanisms of GPCR-G protein recognition

Naveen Thakur,
Arka P. Ray,
Liam Sharp,
Beining Jin,
Alexander Duong,
Niloofar Gopal Pour,
Samuel Obeng,
Anuradha V. Wijesekara,
Zhan-Guo Gao,
Christopher R. McCurdy,
Kenneth A. Jacobson,
Edward Lyman,
Matthew T. Eddy

Affiliations

Naveen Thakur: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Arka P. Ray: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Liam Sharp: Department of Physics and Astronomy, University of Delaware
Beining Jin: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Alexander Duong: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Niloofar Gopal Pour: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Samuel Obeng: Department of Pharmacodynamics, College of Pharmacy, University of Florida
Anuradha V. Wijesekara: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida
Zhan-Guo Gao: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Christopher R. McCurdy: Department of Medicinal Chemistry, College of Pharmacy, University of Florida
Kenneth A. Jacobson: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Edward Lyman: Department of Physics and Astronomy, University of Delaware
Matthew T. Eddy: Department of Chemistry, College of Liberal Arts & Sciences, University of Florida

DOI: https://doi.org/10.1038/s41467-023-36425-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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In cell membranes, lipids are ubiquitous regulators of protein function. Here, Thakur et al. observe anionic phospholipids impact the conformational dynamics of a class A human GPCR.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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