Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo

Bharath Sunchu; Nicole MynYi Lee; Jennifer A. Taylor; Roberto Carlos Segura; Chantal Roubinet; Clemens Cabernard

doi:10.1038/s42003-022-03874-z

Communications Biology (Sep 2022)

Asymmetric chromatin retention and nuclear envelopes separate chromosomes in fused cells in vivo

Bharath Sunchu,
Nicole MynYi Lee,
Jennifer A. Taylor,
Roberto Carlos Segura,
Chantal Roubinet,
Clemens Cabernard

Affiliations

Bharath Sunchu: Department of Biology, University of Washington
Nicole MynYi Lee: Department of Biology, University of Washington
Jennifer A. Taylor: Department of Biology, University of Washington
Roberto Carlos Segura: Department of Biology, University of Washington
Chantal Roubinet: Medical Research Council Laboratory of Molecular Biology, University of Cambridge
Clemens Cabernard: Department of Biology, University of Washington

DOI: https://doi.org/10.1038/s42003-022-03874-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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A hybrid fly cell model to test the separation of chromosomes of different origin. Neural stem cell (NB) - ganglion mother cell (GMC) hybrids align the respective chromosomes independently, supported by NB- or GMC-derived centrosomes and their spindles.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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