BMC Medical Genetics (Dec 2011)

Meta-analysis of 8q24 for seven cancers reveals a locus between <it>NOV </it>and <it>ENPP2 </it>associated with cancer development

  • Brisbin Abra G,
  • Asmann Yan W,
  • Song Honglin,
  • Tsai Ya-Yu,
  • Aakre Jeremiah A,
  • Yang Ping,
  • Jenkins Robert B,
  • Pharoah Paul,
  • Schumacher Fredrick,
  • Conti David V,
  • Duggan David J,
  • Jenkins Mark,
  • Hopper John,
  • Gallinger Steven,
  • Newcomb Polly,
  • Casey Graham,
  • Sellers Thomas A,
  • Fridley Brooke L

DOI
https://doi.org/10.1186/1471-2350-12-156
Journal volume & issue
Vol. 12, no. 1
p. 156

Abstract

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Abstract Background Human chromosomal region 8q24 contains several genes which could be functionally related to cancer, including the proto-oncogene c-MYC. However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24. Methods In this study, we completed a meta-analysis of results from nine genome-wide association studies for seven types of solid-tumor cancers (breast, prostate, pancreatic, lung, ovarian, colon, and glioma) to identify additional associations that were not apparent in any individual study. Results Fifteen SNPs in the 8q24 region had meta-analysis p-values NOV and ENPP2, which have been shown to play a role in tumor development and motility. An additional region consisting of 5 markers from 128,478,000 bp - 128,524,000 (around gene POU5F1B) had p-values Conclusions Further research in this area is warranted as these results demonstrate that the chromosomal region 8q24 may contain a locus that influences general cancer susceptibility between 120,576 and 120,630 kb.