Nature Communications (May 2021)
Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
- Makoto Saito,
- Yasushi Itoh,
- Fumihiko Yasui,
- Tsubasa Munakata,
- Daisuke Yamane,
- Makoto Ozawa,
- Risa Ito,
- Takayuki Katoh,
- Hirohito Ishigaki,
- Misako Nakayama,
- Shintaro Shichinohe,
- Kenzaburo Yamaji,
- Naoki Yamamoto,
- Ai Ikejiri,
- Tomoko Honda,
- Takahiro Sanada,
- Yoshihiro Sakoda,
- Hiroshi Kida,
- Thi Quynh Mai Le,
- Yoshihiro Kawaoka,
- Kazumasa Ogasawara,
- Kyoko Tsukiyama-Kohara,
- Hiroaki Suga,
- Michinori Kohara
Affiliations
- Makoto Saito
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Yasushi Itoh
- Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Setatsukinowa
- Fumihiko Yasui
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Tsubasa Munakata
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Daisuke Yamane
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Makoto Ozawa
- Transboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University
- Risa Ito
- Department of Chemistry, Graduate School of Science, The University of Tokyo
- Takayuki Katoh
- Department of Chemistry, Graduate School of Science, The University of Tokyo
- Hirohito Ishigaki
- Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Setatsukinowa
- Misako Nakayama
- Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Setatsukinowa
- Shintaro Shichinohe
- Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Setatsukinowa
- Kenzaburo Yamaji
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Naoki Yamamoto
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Ai Ikejiri
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Tomoko Honda
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Takahiro Sanada
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- Yoshihiro Sakoda
- Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University
- Hiroshi Kida
- Hokkaido University Research Center for Zoonosis Control
- Thi Quynh Mai Le
- National Institute of Hygiene and Epidemiology
- Yoshihiro Kawaoka
- Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
- Kazumasa Ogasawara
- Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Setatsukinowa
- Kyoko Tsukiyama-Kohara
- Transboundary Animal Diseases Center, Joint Faculty of Veterinary Medicine, Kagoshima University
- Hiroaki Suga
- Department of Chemistry, Graduate School of Science, The University of Tokyo
- Michinori Kohara
- Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
- DOI
- https://doi.org/10.1038/s41467-021-22964-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models.
