Nature Communications (Dec 2018)
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes
- Alessandra Fiore,
- Stefano Ugel,
- Francesco De Sanctis,
- Sara Sandri,
- Giulio Fracasso,
- Rosalinda Trovato,
- Silvia Sartoris,
- Samantha Solito,
- Susanna Mandruzzato,
- Fulvia Vascotto,
- Keli L. Hippen,
- Giada Mondanelli,
- Ursula Grohmann,
- Geny Piro,
- Carmine Carbone,
- Davide Melisi,
- Rita T. Lawlor,
- Aldo Scarpa,
- Alessia Lamolinara,
- Manuela Iezzi,
- Matteo Fassan,
- Silvio Bicciato,
- Bruce R. Blazar,
- Ugur Sahin,
- Peter J. Murray,
- Vincenzo Bronte
Affiliations
- Alessandra Fiore
- Department of Medicine, Section of Immunology, University of Verona
- Stefano Ugel
- Department of Medicine, Section of Immunology, University of Verona
- Francesco De Sanctis
- Department of Medicine, Section of Immunology, University of Verona
- Sara Sandri
- Department of Medicine, Section of Immunology, University of Verona
- Giulio Fracasso
- Department of Medicine, Section of Immunology, University of Verona
- Rosalinda Trovato
- Department of Medicine, Section of Immunology, University of Verona
- Silvia Sartoris
- Department of Medicine, Section of Immunology, University of Verona
- Samantha Solito
- Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova
- Susanna Mandruzzato
- Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova
- Fulvia Vascotto
- TRON-Translational Oncology, University Medical Center of Johannes Gutenberg University
- Keli L. Hippen
- Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota
- Giada Mondanelli
- Department of Experimental Medicine, University of Perugia
- Ursula Grohmann
- Department of Experimental Medicine, University of Perugia
- Geny Piro
- Department of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of Verona
- Carmine Carbone
- Department of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of Verona
- Davide Melisi
- Department of Medicine, Digestive Molecular Clinical Oncology Research Unit, University of Verona
- Rita T. Lawlor
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Aldo Scarpa
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Alessia Lamolinara
- Department of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), University G. D’Annunzio of Chieti-Pescara
- Manuela Iezzi
- Department of Medicine and Aging Science, Center of Excellence on Aging and Translational Medicine (CeSi-Met), University G. D’Annunzio of Chieti-Pescara
- Matteo Fassan
- Department of Medicine-DIMED, University of Padova
- Silvio Bicciato
- Department of Life Sciences, Center for Genome Research, University of Modena and Reggio Emilia
- Bruce R. Blazar
- Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota
- Ugur Sahin
- TRON-Translational Oncology, University Medical Center of Johannes Gutenberg University
- Peter J. Murray
- Max Planck Institute of Biochemistry
- Vincenzo Bronte
- Department of Medicine, Section of Immunology, University of Verona
- DOI
- https://doi.org/10.1038/s41467-018-07654-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therapy, and employ ectopic FLIP to treat immunopathology.
