Open Access Journal of Clinical Trials (Apr 2023)

A Multidomain Intervention Program for Older People with Dementia: A Pilot Study

  • Xuan Nguyen T,
  • Thi Thanh Vu H,
  • Nguyen T,
  • Esterman A,
  • Viet Tran L,
  • Thillainadesan J,
  • Naganathan V,
  • Brodaty H,
  • Trung Nguyen A

Journal volume & issue
Vol. Volume 15
pp. 1 – 10

Abstract

Read online

Thanh Xuan Nguyen,1,2 Huyen Thi Thanh Vu,1,2 Tuan Nguyen,3– 6 Adrian Esterman,5 Luc Viet Tran,1,2 Janani Thillainadesan,7,8 Vasikaran Naganathan,7,8 Henry Brodaty,9 Anh Trung Nguyen1,2 1Scientific Research Department, National Geriatric Hospital, Hanoi, 10000, Vietnam; 2Department of Geriatrics, Hanoi Medical University, Hanoi, 10000, Vietnam; 3Division of Social Gerontology, National Ageing Research Institute, Parkville, VIC, 3050, Australia; 4School of Health Sciences, Swinburne University of Technology, Hawthorn, VIC, 3122, Australia; 5UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia; 6Health Strategy and Policy Institute, Ministry of Health of Vietnam, Hanoi, 10000, Vietnam; 7Department of Geriatric Medicine and Centre for Education and Research on Ageing (CERA), Concord Hospital, Sydney, NSW, Australia; 8Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia; 9Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, UNSW, Sydney, NSW, AustraliaCorrespondence: Thanh Xuan Nguyen, Scientific Research Department, National Geriatric Hospital, 1A, Phuong Mai, Dong Da, Hanoi, 10000, Vietnam, Tel +84 983277646, Email [email protected]: Multidomain interventions have been shown to be effective in improving cognition, quality of life, reducing neuropsychiatric symptoms and delaying progression of functional impairment or disability in dementia patients. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, this pilot study will assess the feasibility of a multidomain intervention for older people with dementia in nursing homes in Vietnam.Methods: Participants will be randomized into two equal groups, to receive either a multidomain intervention (intervention group) or regular health advice (control group). The intervention will include physical, cognitive, and social interventions as well as management of metabolic and vascular risk factors. We will hypothesize that the multidomain intervention will be feasible in Vietnam, and participants who receive the intervention will show improvement in quality of life, behaviors, functional ability, cognitive function, sleep, and in reduction of falls, use of healthcare services, and death rate compared to those in the control group during the 6 months intervention period and after the 6 months extended follow-up.Discussion: This is the first study to evaluate the feasibility of a multidomain intervention program for older people with dementia in nursing homes in Vietnam. The results from the trial will inform clinicians and the public of the possibility of comprehensive treatment beyond simply drug treatments for dementia. This paves the way for further studies to evaluate the long-term effects of multidomain interventions in dementia patients. Furthermore, the research results will provide information on the effectiveness of multidomain interventions which will inform policy development on dementia.Trial Registration: The trial is registered with ClinicalTrials.gov identifier: NCT04948450 on 02/07/2021.Keywords: dementia, multidomain, intervention, feasibility

Keywords