Effect of sevoflurane on neuronal activity during deep brain stimulation surgery for epilepsy: A case report

Michaël J. Bos, MD; Linda Ackermans, MD, PhD; Frédéric L.W.V.J. Schaper, MD; Rob P.W. Rouhl, MD, PhD; Vivianne H.J.M. van Kranen-Mastenbroek, MD, PhD; Wolfgang F. Buhre, MD, PhD; Marcus L.F. Janssen, MD, PhD

Interdisciplinary Neurosurgery (Jun 2018)

Effect of sevoflurane on neuronal activity during deep brain stimulation surgery for epilepsy: A case report

Michaël J. Bos, MD,
Linda Ackermans, MD, PhD,
Frédéric L.W.V.J. Schaper, MD,
Rob P.W. Rouhl, MD, PhD,
Vivianne H.J.M. van Kranen-Mastenbroek, MD, PhD,
Wolfgang F. Buhre, MD, PhD,
Marcus L.F. Janssen, MD, PhD

Affiliations

Michaël J. Bos, MD: Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center, Maastricht, The Netherlands; School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Linda Ackermans, MD, PhD: Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Frédéric L.W.V.J. Schaper, MD: School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands
Rob P.W. Rouhl, MD, PhD: School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands; Academic Center for Epileptology Kempenhaeghe/MUMC+, Heeze and Maastricht, The Netherlands
Vivianne H.J.M. van Kranen-Mastenbroek, MD, PhD: Department of Neurophysiology, Maastricht University Medical Center, Maastricht, The Netherlands
Wolfgang F. Buhre, MD, PhD: Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
Marcus L.F. Janssen, MD, PhD: School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Neurophysiology, Maastricht University Medical Center, Maastricht, The Netherlands; Corresponding author at: Department of Neurology, P. Debyelaan 25, Postbus 5800, 6202 AZ Maastricht, The Netherlands.

Journal volume & issue: Vol. 12
pp. 56 – 58

Abstract

Read online

Deep brain stimulation of the anterior nucleus of the thalamus is an effective treatment for patients with refractory epilepsy who do not respond sufficiently to medical therapy. Optimal therapeutic effects of deep brain stimulation probably depend on accurate positioning of the stimulating electrodes. Microelectrode recordings show bursty firing neurons in the anterior nucleus of the thalamus region, which confirms the anatomical target determined by the surgeon. Deep brain stimulation electrodes in epilepsy patients are implanted under general anesthesia. The type and depth of anesthesia might interfere with microelectrode ecordings. Here, we describe our experience of a patient who underwent deep brain stimulation surgery under general anesthesia with sevoflurane, a volatile anesthetic, and its effect on the microelectrode recordings. Keywords: Thalamus, Deep brain stimulation, Sevoflurane

Published in Interdisciplinary Neurosurgery

ISSN: 2214-7519 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Surgery; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/interdisciplinary-neurosurgery/

About the journal