The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer
Richard D Neal,
David Hammond,
Matthew E J Callister,
Stephen J Sharp,
Andrew Smith,
Matthew Ward,
Juliet A Usher-Smith,
Sabrina H Rossi,
Neil Hancock,
Grant D Stewart,
Jon Cartledge,
Michael Kimuli,
Philip A J Crosbie,
Evis Sala,
Suzanne Rogerson,
Sarah W Burge,
Tom Wallace,
Irene Simmonds,
Fiona Farquhar,
Angela Godoy,
Simon Burbidge,
Claire Eckert,
Gareth R Iball,
Golnessa Masson
Affiliations
Richard D Neal
College of Medicine and Health, University of Exeter, Exeter, UK
David Hammond
Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Matthew E J Callister
Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Stephen J Sharp
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
Andrew Smith
Upper Gastro-intestinal and Pancreas Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Matthew Ward
Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK
Juliet A Usher-Smith
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Sabrina H Rossi
Department of Surgery, University of Cambridge, Cambridge, UK
Neil Hancock
Leeds Diagnosis & Screening Unit, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
Grant D Stewart
Department of Surgery, University of Cambridge, Cambridge, UK
Jon Cartledge
Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK
Michael Kimuli
Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK
Philip A J Crosbie
Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Evis Sala
Department of Radiology, University of Cambridge, Cambridge, UK
Suzanne Rogerson
Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Sarah W Burge
Department of Oncology, University of Cambridge, Cambridge, UK
Tom Wallace
Leeds Vascular Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Irene Simmonds
Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK
Fiona Farquhar
Research and Innovation, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Angela Godoy
Department of Surgery, University of Cambridge, Cambridge, UK
Simon Burbidge
Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, UK
Claire Eckert
Leeds Institiute of Health Sciences, University of Leeds, Leeds, UK
Gareth R Iball
Department of Medical Physics & Engineering, Leeds teaching hospitals NHS Trust, Leeds, UK
Golnessa Masson
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Introduction Kidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening programme for RCC. The Yorkshire Kidney Screening Trial (YKST) will assess the feasibility of adding non-contrast abdominal CT scanning to screen for RCC and other abdominal pathology within the Yorkshire Lung Screening Trial (YLST), a randomised trial of community-based CT screening for lung cancer.Methods and analysis In YLST, ever-smokers aged 55–80 years registered with a general practice in Leeds have been randomised to a Lung Health Check assessment, including a thoracic low-dose CT (LDCT) for those at high risk of lung cancer, or routine care. YLST participants randomised to the Lung Health Check arm who attend for the second round of screening at 2 years without a history of RCC or abdominal CT scan within the previous 6 months will be invited to take part in YKST. We anticipate inviting 4700 participants. Those who consent will have an abdominal CT immediately following their YLST thoracic LDCT. A subset of participants and the healthcare workers involved will be invited to take part in a qualitative interview. Primary objectives are to quantify the uptake of the abdominal CT, assess the acceptability of the combined screening approach and pilot the majority of procedures for a subsequent randomised controlled trial of RCC screening within lung cancer screening.Ethics and dissemination YKST was approved by the North West-Preston Research Ethics Committee (21/NW/0021), and the Health Research Authority on 3 February 2021. Trial results will be disseminated at clinical meetings, in peer-reviewed journals and to policy-makers. Findings will be made available to participants via the study website (www.YKST.org).Trial registration numbers NCT05005195 and ISRCTN18055040.
