Clinical spectrum and prognostic markers of multi-system inflammatory syndrome in children hospitalised in Northern India

Abstract

Background: Multi-system inflammatory syndrome in children (MIS-C) is characterized by hyper-inflammation and multi-organ dysfunction with antecedent SARS-CoV-2 infection. To describe clinical, laboratory characteristics and outcome of children with MIS-C in a low-middle-income-country and to evaluate factors associated with mortality. Methods: Cases ( 50 mg/L [aOR 9.6 (95% CI 1.8–50.9)] and Prothrombin Time (PT) > 17 seconds at presentation [aOR 13.6 (95% CI 1.6–118.9)] to be independently associated with mortality. Need of MV emerged as independent predictor of mortality on Model 2. Conclusions: Children with MIS-C having high CRP and PT at presentation are at increased odds of dying and require intensive monitoring.

Keywords

• Multi-system inflammatory syndrome
• MIS-C
• COVID-19
• SARS-CoV2
• Inflammatory
• Cytokine storm