Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Karl Bacos; Linn Gillberg; Petr Volkov; Anders H Olsson; Torben Hansen; Oluf Pedersen; Anette Prior Gjesing; Hans Eiberg; Tiinamaija Tuomi; Peter Almgren; Leif Groop; Lena Eliasson; Allan Vaag; Tasnim Dayeh; Charlotte Ling

doi:10.1038/ncomms11089

Nature Communications (Mar 2016)

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Karl Bacos,
Linn Gillberg,
Petr Volkov,
Anders H Olsson,
Torben Hansen,
Oluf Pedersen,
Anette Prior Gjesing,
Hans Eiberg,
Tiinamaija Tuomi,
Peter Almgren,
Leif Groop,
Lena Eliasson,
Allan Vaag,
Tasnim Dayeh,
Charlotte Ling

Affiliations

Karl Bacos: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre
Linn Gillberg: Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet
Petr Volkov: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre
Anders H Olsson: Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Anette Prior Gjesing: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Hans Eiberg: Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen
Tiinamaija Tuomi: Department of Endocrinology, Abdominal Centre, Helsinki University Hospital
Peter Almgren: Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre
Leif Groop: Finnish Institute for Molecular Medicine, University of Helsinki
Lena Eliasson: Department of Clinical Sciences, Islet cell exocytosis, Lund University Diabetes Centre
Allan Vaag: Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet
Tasnim Dayeh: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre
Charlotte Ling: Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre

DOI: https://doi.org/10.1038/ncomms11089
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Aging is associated with impaired pancreatic islet function, increased risk of type 2 diabetes, and changes in DNA methylation. Here the authors find blood-based biomarkers that reflect age-associated DNA methylation changes in human pancreatic islets associated with insulin secretion and diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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