Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

Abstract

It is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated proliferation within the endocardium.