Synthesis new fluorinated 4-phenyl-1,4-dihydropyridine derivatives, as perspective antiarrhythmic and antihypertensive drugs

Abstract

Derivatives of dihydropyridines are promising agents for research, as they have high biological activity. Their low toxicity and polytargeted properties make it possible to create new derivatives and identify new biological activity. As part of this work, we have obtained six new fluorinated derivatives of 4-phenyl-1,4-dihydropyridines. These compounds were synthesized by a modified Hantzsch reaction, the interaction of polyfluorinated sulfur-containing benzaldehydes with ethyl acetoacetate and ethyl 3-aminobut-2-enoate. Studies on the isolated atrium have shown that the possible mechanism of action of the dihydropyridine derivatives lies in the blockade of beta-adrenergic receptors. At the same time, it is not a blocker of potassium and calcium channels. The fluorinated 4-phenyl-1,4-dihydropyridine derivatives, with SCF2H (decrease pressure) and SO2CH3 (increase pressure) groups showed pronounced activity in the study of these derivatives on the blood pressure of rats.

Keywords

• Sulfur-containing fluorinated 1,4-dihydropyridines
• Antiarrhythmic effect
• Blood pressure