Total synthesis of teixobactin

Kang Jin; Iek Hou Sam; Kathy Hiu Laam Po; Du’an Lin; Ebrahim H. Ghazvini Zadeh; Sheng Chen; Yu Yuan; Xuechen Li

doi:10.1038/ncomms12394

Nature Communications (Aug 2016)

Total synthesis of teixobactin

Kang Jin,
Iek Hou Sam,
Kathy Hiu Laam Po,
Du’an Lin,
Ebrahim H. Ghazvini Zadeh,
Sheng Chen,
Yu Yuan,
Xuechen Li

Affiliations

Kang Jin: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong
Iek Hou Sam: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong
Kathy Hiu Laam Po: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Du’an Lin: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong
Ebrahim H. Ghazvini Zadeh: Department of Chemistry, University of Central Florida
Sheng Chen: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Yu Yuan: Department of Chemistry, University of Central Florida
Xuechen Li: Department of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong

DOI: https://doi.org/10.1038/ncomms12394
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 6

Abstract

Read online

Teixobactin is a recently identified antibiotic that shows activity against drug resistant strains of bacteria. Here, the authors report a highly convergent total synthesis of this natural product, with sufficient flexibility to also allow the synthesis of a number of analogues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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