Nature Communications (Aug 2016)

Total synthesis of teixobactin

  • Kang Jin,
  • Iek Hou Sam,
  • Kathy Hiu Laam Po,
  • Du’an Lin,
  • Ebrahim H. Ghazvini Zadeh,
  • Sheng Chen,
  • Yu Yuan,
  • Xuechen Li

DOI
https://doi.org/10.1038/ncomms12394
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 6

Abstract

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Teixobactin is a recently identified antibiotic that shows activity against drug resistant strains of bacteria. Here, the authors report a highly convergent total synthesis of this natural product, with sufficient flexibility to also allow the synthesis of a number of analogues.