Nature Communications (Jan 2022)
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
- Phyllis F. Cheung,
- JiaJin Yang,
- Rui Fang,
- Arianna Borgers,
- Kirsten Krengel,
- Anne Stoffel,
- Kristina Althoff,
- Chi Wai Yip,
- Elaine H. L. Siu,
- Linda W. C. Ng,
- Karl S. Lang,
- Lamin B. Cham,
- Daniel R. Engel,
- Camille Soun,
- Igor Cima,
- Björn Scheffler,
- Jana K. Striefler,
- Marianne Sinn,
- Marcus Bahra,
- Uwe Pelzer,
- Helmut Oettle,
- Peter Markus,
- Esther M. M. Smeets,
- Erik H. J. G. Aarntzen,
- Konstantinos Savvatakis,
- Sven-Thorsten Liffers,
- Smiths S. Lueong,
- Christian Neander,
- Anna Bazarna,
- Xin Zhang,
- Annette Paschen,
- Howard C. Crawford,
- Anthony W. H. Chan,
- Siu Tim Cheung,
- Jens T. Siveke
Affiliations
- Phyllis F. Cheung
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- JiaJin Yang
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Rui Fang
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Arianna Borgers
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Kirsten Krengel
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Anne Stoffel
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Kristina Althoff
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Chi Wai Yip
- Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Elaine H. L. Siu
- Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Linda W. C. Ng
- Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Karl S. Lang
- Institute of Immunology, Medical Faculty, University of Duisburg-Essen
- Lamin B. Cham
- Institute of Immunology, Medical Faculty, University of Duisburg-Essen
- Daniel R. Engel
- Department of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen
- Camille Soun
- Department of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen
- Igor Cima
- DKFZ-Division Translational Neurooncology at the WTZ, German Cancer Consortium (DKTK partner site Essen/Düsseldorf)
- Björn Scheffler
- DKFZ-Division Translational Neurooncology at the WTZ, German Cancer Consortium (DKTK partner site Essen/Düsseldorf)
- Jana K. Striefler
- Universitätsmedizin Charité Berlin, CONKO Study Group, Department of Medical Oncology, Haematology and Tumorimmunology
- Marianne Sinn
- Universitätsmedizin Charité Berlin, CONKO Study Group, Department of Medical Oncology, Haematology and Tumorimmunology
- Marcus Bahra
- Department of Surgical Oncology and Robotics, Krankenhaus Waldfriede
- Uwe Pelzer
- Medical Department, Division of Hematology, Oncology and Tumor Immunology, Charité University Hospital
- Helmut Oettle
- Praxis und Tagesklinik
- Peter Markus
- Department of General, Visceral and Trauma Surgery, Elisabeth Hospital Essen
- Esther M. M. Smeets
- Department of Medical Imaging, Radboud university medical Center
- Erik H. J. G. Aarntzen
- Department of Medical Imaging, Radboud university medical Center
- Konstantinos Savvatakis
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Sven-Thorsten Liffers
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Smiths S. Lueong
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Christian Neander
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Anna Bazarna
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Xin Zhang
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- Annette Paschen
- Department of Dermatology, University Hospital Essen, University of Duisburg-Essen
- Howard C. Crawford
- Rogel Comprehensive Cancer Center, University of Michigan
- Anthony W. H. Chan
- Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Siu Tim Cheung
- Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Jens T. Siveke
- Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen
- DOI
- https://doi.org/10.1038/s41467-021-27088-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.
