mBio
(Apr 2021)
Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection
C. N. Jondle,
K. E. Johnson,
C. Aurubin,
P. Sylvester,
G. Xin,
W. Cui,
A. R. Huppler,
V. L. Tarakanova
Affiliations
C. N. Jondle
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
K. E. Johnson
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
C. Aurubin
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
P. Sylvester
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
G. Xin
Blood Research Institute, Versiti, Milwaukee, Wisconsin, USA
W. Cui
Blood Research Institute, Versiti, Milwaukee, Wisconsin, USA
A. R. Huppler
Department of Pediatrics, Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
V. L. Tarakanova
ORCiD Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
DOI
https://doi.org/10.1128/mBio.00566-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
Gammaherpesviruses establish lifelong infections in a majority of humans and are associated with B cell lymphomas. IL-17A is a host cytokine that plays a well-established role in the clearance of bacterial and fungal infections; however, the role of IL-17A in viral infections is poorly understood.
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