Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection

C. N. Jondle; K. E. Johnson; C. Aurubin; P. Sylvester; G. Xin; W. Cui; A. R. Huppler; V. L. Tarakanova

doi:10.1128/mBio.00566-21

mBio (Apr 2021)

Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection

C. N. Jondle,
K. E. Johnson,
C. Aurubin,
P. Sylvester,
G. Xin,
W. Cui,
A. R. Huppler,
V. L. Tarakanova

Affiliations

C. N. Jondle: Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
K. E. Johnson: Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
C. Aurubin: Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
P. Sylvester: Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
G. Xin: Blood Research Institute, Versiti, Milwaukee, Wisconsin, USA
W. Cui: Blood Research Institute, Versiti, Milwaukee, Wisconsin, USA
A. R. Huppler: Department of Pediatrics, Children’s Hospital of Wisconsin Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
V. L. Tarakanova: ORCiD; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

DOI: https://doi.org/10.1128/mBio.00566-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Gammaherpesviruses establish lifelong infections in a majority of humans and are associated with B cell lymphomas. IL-17A is a host cytokine that plays a well-established role in the clearance of bacterial and fungal infections; however, the role of IL-17A in viral infections is poorly understood.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal