European Journal of Medical Research (Nov 2022)
Prognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection
- Johannes C. Fischer,
- Vera Balz,
- Danny Jazmati,
- Edwin Bölke,
- Noemi F. Freise,
- Verena Keitel,
- Torsten Feldt,
- Björn-Erik Ole Jensen,
- Johannes Bode,
- Tom Lüdde,
- Dieter Häussinger,
- Ortwin Adams,
- E. Marion Schneider,
- Jürgen Enczmann,
- Jutta M. Rox,
- Derik Hermsen,
- Karin Schulze-Bosse,
- Detlef Kindgen-Milles,
- Wolfram Trudo Knoefel,
- Martijn van Griensven,
- Jan Haussmann,
- Balint Tamaskovics,
- Christian Plettenberg,
- Kathrin Scheckenbach,
- Stefanie Corradini,
- Alessia Pedoto,
- Kitti Maas,
- Livia Schmidt,
- Olaf Grebe,
- Irene Esposito,
- Anja Ehrhardt,
- Matthias Peiper,
- Bettina Alexandra Buhren,
- Christian Calles,
- Andreas Stöhr,
- Peter Arne Gerber,
- Artur Lichtenberg,
- Hubert Schelzig,
- Yechan Flaig,
- Amir Rezazadeh,
- Wilfried Budach,
- Christiane Matuschek
Affiliations
- Johannes C. Fischer
- Institute for Transplant Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Vera Balz
- Institute for Transplant Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Danny Jazmati
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Edwin Bölke
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Noemi F. Freise
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Verena Keitel
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Torsten Feldt
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Björn-Erik Ole Jensen
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Johannes Bode
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Tom Lüdde
- Institute for Virology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Dieter Häussinger
- Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Ortwin Adams
- Institute for Virology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- E. Marion Schneider
- Division of Experimental Anesthesiology, University Hospital Ulm
- Jürgen Enczmann
- Institute for Transplant Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Jutta M. Rox
- Institute for Transplant Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Derik Hermsen
- Central Institute for Laboratory Diagnostics and Clinical Chemistry, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Karin Schulze-Bosse
- Central Institute for Laboratory Diagnostics and Clinical Chemistry, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Detlef Kindgen-Milles
- Department of Anesthesiology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Wolfram Trudo Knoefel
- Department of Surgery and Interdisciplinary Surgical Intensive Care Unit, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Martijn van Griensven
- Department cBITE, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University
- Jan Haussmann
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Balint Tamaskovics
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Christian Plettenberg
- Department of Ear, Nose and Throat Disease, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Kathrin Scheckenbach
- Department of Ear, Nose and Throat Disease, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Stefanie Corradini
- Department of Radiation Oncology, LMU University of Munich
- Alessia Pedoto
- Department of Anesthesiology, Memorial Sloan Kettering Cancer Center
- Kitti Maas
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Livia Schmidt
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Olaf Grebe
- Department of Cardiology and Rhythmology, Petrus Hospital
- Irene Esposito
- Institute of Pathology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Anja Ehrhardt
- Institute of Virology, University of Witten/Herdecke
- Matthias Peiper
- Medical Faculty, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Bettina Alexandra Buhren
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Christian Calles
- Coordination Center for Clinical Studies, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Andreas Stöhr
- Coordination Center for Clinical Studies, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Peter Arne Gerber
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Artur Lichtenberg
- Department of Cardiac Surgery, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Hubert Schelzig
- Department of Vascular Surgery, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Yechan Flaig
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Amir Rezazadeh
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Wilfried Budach
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- Christiane Matuschek
- Department of Radiation Oncology, Medical Faculty, University Hospital Dusseldorf, Heinrich-Heine-University Dusseldorf
- DOI
- https://doi.org/10.1186/s40001-022-00864-z
- Journal volume & issue
-
Vol. 27,
no. 1
pp. 1 – 12
Abstract
Abstract Background The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA variants and differential COVID-19 outcomes and have shown that HLA genotypes are associated with differential immune responses against SARS-CoV-2, particularly in severely ill patients. Information, whether HLA haplotypes are associated with the severity or length of the disease in moderately diseased individuals is absent. Methods Next-generation sequencing-based HLA typing was performed in 303 female and 231 male non-hospitalized North Rhine Westphalian patients infected with SARS-CoV2 during the first and second wave. For HLA-Class I, we obtained results from 528 patients, and for HLA-Class II from 531. In those patients, who became ill between March 2020 and January 2021, the 22 most common HLA-Class I (HLA-A, -B, -C) or HLA-Class II (HLA –DRB1/3/4, -DQA1, -DQB1) haplotypes were determined. The identified HLA haplotypes as well as the presence of a CCR5Δ32 mutation and number of O and A blood group alleles were associated to disease severity and duration of the disease. Results The influence of the HLA haplotypes on disease severity and duration was more pronounced than the influence of age, sex, or ABO blood group. These associations were sex dependent. The presence of mutated CCR5 resulted in a longer recovery period in males. Conclusion The existence of certain HLA haplotypes is associated with more severe disease.
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