Apheresis Platelets: A Study of Effect of Donor Variables on Outcome of Plateletpheresis

Abstract

Introduction: Use of single donor platelets (SDP) has increased by leaps and bounds over past few years. SDP not only increase the purity of product in terms of decreased cellular contamination but also increases the overall yield of platelet collected. However, yield of SDP is known to be influenced by various donor variables. Aim: To study the effect of various donor variables such as age, weight, height, pre donation Hb concentration, TLC, platelet count and indices on the yield of platelets. Materials and Methods: The present study included the outcome of 225 plateletpheresis procedures that were conducted on Haemonetics MCS+ intermittent flow cell separator (Haemonetic Corporation, Braintree, Massachusetts, USA). Statistical analysis was done to establish cause and effect relationship and to find the extent of relationship between different variables. Results: Platelet yield showed high statistical significance with pre donation platelet count and its indices (p =0.001). Statistical significant negative correlation was seen between pre donation Hb concentration and the platelet yield (p =0.003). No statistical significance was seen height (p=0.708), weight (p=0.217) and pre donation WBC count (p=0.217) of donor on platelet yield. Conclusion: Identification of interventions that could increase pre donation platelet would have a substantial beneficiary effect on platelet product yields and thereby leading to better platelet recovery in the recipient.

Keywords

• haemoglobin
• transfusion
• yield