Nature Communications (Nov 2019)
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
- Rachel Eyre,
- Denis G. Alférez,
- Angélica Santiago-Gómez,
- Kath Spence,
- James C. McConnell,
- Claire Hart,
- Bruno M. Simões,
- Diane Lefley,
- Claudia Tulotta,
- Joanna Storer,
- Austin Gurney,
- Noel Clarke,
- Mick Brown,
- Sacha J. Howell,
- Andrew H. Sims,
- Gillian Farnie,
- Penelope D. Ottewell,
- Robert B. Clarke
Affiliations
- Rachel Eyre
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Denis G. Alférez
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Angélica Santiago-Gómez
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Kath Spence
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- James C. McConnell
- Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester
- Claire Hart
- Genito Urinary Cancer Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Bruno M. Simões
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Diane Lefley
- Academic Unit of Clinical Oncology, Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield
- Claudia Tulotta
- Academic Unit of Clinical Oncology, Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield
- Joanna Storer
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Austin Gurney
- OncoMed Pharmaceuticals
- Noel Clarke
- Department of Urology, Salford Royal Hospital NHS Foundation Trust, Stott Lane
- Mick Brown
- Genito Urinary Cancer Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Sacha J. Howell
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Andrew H. Sims
- Applied Bioinformatics of Cancer Group, Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Gillian Farnie
- Structural Genomics Consortium, NDORMS, Botnar Research Centre
- Penelope D. Ottewell
- Academic Unit of Clinical Oncology, Department of Oncology and Metabolism, Mellanby Centre for Bone Research, University of Sheffield
- Robert B. Clarke
- Breast Biology Group, Manchester Breast Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- DOI
- https://doi.org/10.1038/s41467-019-12807-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
In breast cancer, dormant cancer cells may develop into bone metastases. Here, the authors demonstrate that microenvironmental IL1β stimulates metastatic breast cancer cell colonisation in the bone via IL1β-NFKB/CREB-Wnt pathway activation and cancer stem cell colony formation
