The RhoA-ROCK pathway in the regulation of T and B cell responses [version 1; referees: 3 approved]

Abstract

Effective immune responses require the precise regulation of dynamic interactions between hematopoietic and non-hematopoietic cells. The Rho subfamily of GTPases, which includes RhoA, is rapidly activated downstream of a diverse array of biochemical and biomechanical signals, and is emerging as an important mediator of this cross-talk. Key downstream effectors of RhoA are the Rho kinases, or ROCKs. The ROCKs are two serine-threonine kinases that can act as global coordinators of a tissue’s response to stress and injury because of their ability to regulate a wide range of biological processes. Although the RhoA-ROCK pathway has been extensively investigated in the non-hematopoietic compartment, its role in the immune system is just now becoming appreciated. In this commentary, we provide a brief overview of recent findings that highlight the contribution of this pathway to lymphocyte development and activation, and the impact that dysregulation in the activation of RhoA and/or the ROCKs may exert on a growing list of autoimmune and lymphoproliferative disorders.

Keywords

• Animal Genetics
• Biocatalysis
• Cell Adhesion
• Genetics of the Immune System
• Immunomodulation
• Innate Immunity
• Leukemia & Proliferative Disorders of Hematic Cells
• Leukocyte Activation
• Leukocyte Development
• Leukocyte Signaling & Gene Expression
• Lymphomas & Myelomas
• Medical Genetics
• Pediatric Hematology
• Protein Chemistry & Proteomics