Scientific and practical activity of the Department of Molecular Biology of the Palladin Institute of Biochemistry of NAS of Ukraine

Abstract

The present paper gives a detailed analysis of scientific and practical activity of the Department of Molecular Biology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its development. The most important results of the research of molecular mechanisms of regulation of glycolysis and gene expression in malignant tumors upon hypoxia; identification of key transcription factors of the regulation of proliferation and the role of alternative splicing in the regulation of the activity of the different PFKFB isoforms are reported. In recent years, the efforts of the department’s staff have been focused on studying the role of endoplasmic reticulum stress and the regulation of metabolism and proliferation processes at the level of gene expression in genome reprogramming. The obtained results allow to establish the molecular bases­ of pathogenesis of various diseases and to develop new effective methods for their diagnosis, prevention and treatment.